We are studying the molecular and anatomical events of neuroinflammation in multiple sclerosis, in both cell cultures and animal models, in order to find new therapies for this disease
Multiple sclerosis is a degenerative disease of the central nervous system that mainly affects young adults, especially women causing significant health burdens, both individually and in the family and community.
It is a chronic inflammatory disease characterized by damage to the axons (the branches of neurons) and a loss of myelin from neurons in the brain and spinal cord. This occurs as a result of infiltration by white blood cells (lymphocytes and macrophages) and results in the loss of neurological functions. To find new therapies, researchers must understand how this inflammation works.
The group focuses its work on the analysis of phosphodiesterases, enzymes involved in neuroinflammation.
We use cell lines and primary cultures of macrophages, as well as a multiple sclerosis model in mice to find new therapeutic targets to treat this disease. Greater knowledge of the metabolic pathways involved and their alterations will help us identify new drugs capable of modifying the disease’s progression.
The group has seen that some phosphodiesterases involved in neuroinflammation are expressed differently according to the sex of the animals.
We observed a significant reduction of clinical symptoms when mice with experimental autoimmune encephalomyelitis are treated chronically with a phosphodiesterase 7 inhibitor, specific to the cAMP. In the spinal cord of these treated mice changes in the messenger RNA levels of some phosphodiesterases were observed, suggesting a potential treatment for this disease.