Appointment of Mercedes Fernández-Lobato, Group leader
Thanks to research, we develop our knowledge and understand and improve our health

Current research

Problem

The research of this group focuses on identifying the causes and factors that intervene in chronic liver disease, such as cirrhosis and liver cancer, which affect millions of people around the world. It is an essential line of work to identify the still unknown mechanisms that cause these diseases and to describe new therapeutic targets that can prevent and treat them.

The group’s ultimate goal is to reduce morbidity and mortality among patients suffering from chronic liver disease.

Approach

The group works in a cross-disciplinary way towards understand the functioning of angiogenesis (formation of blood vessels) in liver diseases. It is also exploring the mechanisms that favour obesity’s negative impact on liver diseases. And it is working to decipher the main mechanisms through which liver disease becomes liver cancer, and to apply our knowledge to the understanding, prevention and treatment of these diseases.

Impact

The group has contributed significantly to biomedical research in the field of liver disease. It has discovered that angiogenesis is a key element in chronic liver disease and has described the mechanisms involved in the regulation and deregulation of the angiogenesis process.

One of the other goals the group has achieved has been to decipher the mechanisms through which obesity has a negative impact on the evolution of chronic liver disease (from steatosis to liver cancer) and it has also developed therapeutic tools.