Featured publications

Glycogen drives the sensory activation of POMC neurons

Gomez-Valades, Alicia G; Meseguer, David; Varela, Luis; Lienhard, Gabriele; Fernandez, Uxia;

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Horvath, Tamas L; Guinovart, Joan J; Duran, Jordi; Schneeberger, Marc; Claret, Marc.

Reference:
Nature Metabolism 2026.
Deletion of Mfn2 in endothelial cells triggers a mitohormetic response that improves systemic metabolism and healthspan in mice

Chivite, Inigo; Monelli, Erika; Munar-Gelabert, Margalida; Gomez-Valades, Alicia G; Alvarado-Diaz, Abdiel;

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Nogueiras, Rube N; Horvath, Tamas L; De Bock, Katrien; Graupera, Mariona; Claret, Marc.

Reference:
Cell Metabolism 2026.
Rapid modulation of gut microbiota composition by hypothalamic circuits in mice

Toledo, M; Martínez-Martínez, S; Van Hul, M; Laudo, B; Eyre, E;

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Monelli, E; Schwaninger, M; Cani, PD; Nogueiras, R; Claret, M.

Reference:
Nature Metabolism 2025.
Metabolic and feeding adjustments during pregnancy

Haddad-Tóvolli, R; Claret, M;

Reference:
Nature Reviews Endocrinology 2023.
Maternal emulsifier consumption programs offspring metabolic and neuropsychological health in mice

Milà-Guasch, M; Ramírez, S; Llana, SR; Fos-Domènech, J; Dropmann, LM;

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Eyre, E; Gómez-Valadés, AG; Obri, A; Haddad-Tóvolli, R; Claret, M.

Reference:
PLOS BIOLOGY 2023.
Food craving-like episodes during pregnancy are mediated by accumbal dopaminergic circuits

Haddad-Tovolli, Roberta; Ramirez, Sara; Munoz-Moreno, Emma; Mila-Guasch, Maria; Miquel-Rio, Lluis;

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Eyre, Elena; Bortolozzi, Analia; Valjent, Emmanuel; Soria, Guadalupe; Claret, Marc.

Reference:
Nature Metabolism 2022.
Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders

Ramirez, Sara; Haddad-Tovolli, Roberta; Radosevic, Marija; Toledo, Miriam; Pane, Adriana;

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Bruening, Jens C; Fortea, Juan; Jimenez, Amanda; Fernandez-Checa, Jose C; Claret, Marc.

Reference:
Cell Metabolism 2022.
Mitochondrial cristae-remodeling protein OPA1 in POMC neurons couples Ca2+ homeostasis with adipose tissue lipolysis

Gómez-Valadés, AG; Pozo, M; Varela, L; Boudjadja, MB; Ramírez, S;

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Alvarez, C; Nogueiras, R; Garcia-Roves, PM; Horvath, TL; Claret, M.

Reference:
Cell Metabolism 2021.
Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control.

Ramirez, Sara; Gomez-Valades, Alicia G; Schneeberger, Marc; Varela, Luis; Haddad-Tovolli, Roberta;

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Servitja, Joan-Marc; Horvath, Tamas L; Gomis, Ramon; Zorzano, Antonio; Claret, Marc.

Reference:
Cell Metabolism 2017.
Mitofusin 2 in POMC neurons connects ER stress with leptin resistance and energy imbalance

Schneeberger, M; Castaño, C; Garcia, A; Esteban, Y; Gonzalez-Franquesa, A;

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Dietrich, MO; Horvath, TL; Imbernón, M; Nogueiras, R; Bortolozzi, A.

Reference:
CELL 2013.