Gene Regulation in Stem Cells, Cell Plasticity, Differentiation, and Cancer
Featured publications
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Zeb1 induces immune checkpoints to form an immunosuppressive envelope around invading cancer cells
Guo Y; Lu X; Chen Y; Rendon B; Mitchell RA;Cuatrecasas M; Cortés M; Postigo A; Liu Y; Dean DC .Reference:Science Advances 2021.
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ZEB1 promotes inflammation and progression towards inflammation-driven carcinoma through repression of the DNA repair glycosylase MPG in epithelial cells
de Barrios O; Sanchez-Moral L; Cortés M; Ninfali C; Profitós-Pelejà N;(...)Castells A; Maurel J; Salas A; Dean DC; Postigo A .Reference:Gut 2019.
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ZEB1 protects skeletal muscle from damage and is required for its regeneration
Siles, L; Ninfali, C; Cortes, M; Darling, DS; Postigo, A;Reference:Nature Communications 2019.
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Regulation of muscle atrophy-related genes by the opposing transcriptional activities of ZEB1/CtBP and FOXO3
Ninfali C; Siles L; Darling D; Postigo A;Reference:Nucleic Acids Research 2018.
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Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells
Liu Y; Siles L; Lu X; Dean K; Cuatrecasas M;Postigo A; Dean D.Reference:Nature Communications 2018.
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Tumor-associated macrophages (TAMs) depend on ZEB1 for their cancer-promoting roles
Cortes, Marlies; Sanchez-Moral, Lidia; de Barrios, Oriol; Fernandez-Acenero, Maria J.; Martinez-Campanario, M. C.;(...)Darling, Douglas S.; Gyorffy, Balazs; Lawrence, Toby; Dean, Douglas C.; Postigo, Antonio;.Reference:Embo Journal 2017.
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ZEB1-induced tumourigenesis requires senescence inhibition via activation of DKK1/mutant p53/Mdm2/CtBP and repression of macroH2A1
De Barrios O.; Gyorffy B.; Fernández-Aceñero M.J.; Sánchez-Tilló E.; Sánchez-Moral L.;(...)Roué G.; Casal J.I.; Darling D.S.; Castells A.; Postigo A..Reference:Gut 2017.
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Different thresholds of ZEB1 are required for Ras-mediated tumour initiation and metastasis
Liu Y.; Lu X.; Huang L.; Wang W.; Jiang G.;(...)Cuatrecasas M.; Chesney J.; Darling D.S.; Postigo A.; Dean D.C..Reference:Nature Communications 2014.
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The EMT activator ZEB1 promotes tumor growth and determines differential response to chemotherapy in mantle cell lymphoma
Sanchez-Tillo, E; Fanlo, L; Siles, L; Montes-Moreno, S; Moros, A;(...)Martinez, A; Colomer, D; Gyorffy, B; Roue, G; Postigo, A.Reference:Cell Death And Differentiation 2014.
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ZEB1 Promotes invasiveness of colorectal carcinoma cells through the opposing regulation of uPA and PAI-1
Sanchez-Tillo, Ester; de Barrios, Oriol; Siles, Laura; Amendola, Pier G; Darling, Douglas S;Cuatrecasas, Miriam; Castells, Antoni; Postigo, Antonio.Reference:Clinical Cancer Research 2013.