Featured publications

• Conditional BDNF delivery from astrocytes rescues memory deficits, spine density and synaptic properties in the 5xFAD mouse model of Alzheimer disease

  de Pins B; Cifuentes-Díaz C; Farah AT; López-Molina L; Montalban E;

  (...)

  Delgado-García JM; Alberch J; Gruart A; Girault JA; Giralt A .

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  Reference:

  Journal Of Neuroscience 2019.

• Regulation of BDNF release by ARMS/Kidins220 through modulation of Synaptotagmin-IV levels.

  López-Benito S; Sánchez-Sánchez J; Brito V; Calvo L; Lisa S;

  (...)

  Fernández-Fernández S; Bolaños JP; Ginés S; Tessarollo L; Arévalo JC .

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  Reference:

  Journal Of Neuroscience 2018.

• Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation.

  Cariulo C; Azzollini L; Verani M; Martufi P; Boggio R;

  (...)

  Santimone I; Squitieri F; Lashuel HA; Petricca L; Caricasole A .

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  Reference:

  Proceedings Of The National Academy Of Sciences Of The United States Of America 2017.

• 7,8 Dihydroxyflavone ameliorates cognitive and motor deficits in a Huntington's disease mouse model through specific activation of the PLCγ1 pathway.

  García-Díaz Barriga G; Giralt A; Anglada-Huguet M; Gaja-Capdevila N; Orlandi JG;

  Soriano J; Canals JM; Alberch J .

  Reference:

  Human Molecular Genetics 2017.

• Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model.

  Giralt A; Brito V; Chevy Q; Simonnet C; Otsu Y;

  (...)

  Coura R; Alberch J; Ginés S; Poncer JC; Girault JA .

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  Reference:

  Nature Communications 2017.

• Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice

  HD iPSC Consortium;

  Reference:

  Nature Neuroscience 2017.

• Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons

  Mart??n-Ibáñez R; Pardo M; Giralt A; Miguez A; Guardia I;

  (...)

  Alberch J; Girault JA; Chan S; Kastner P; Canals JM.

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  Reference:

  Development 2017.

• Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels

  Rue, Laura; Banez-Coronel, Monica; Creus-Muncunill, Jordi; Giralt, Albert; Alcala-Vida, Rafael;

  (...)

  Aranda, Zeus; Venturi, Veronica; Perez-Navarro, Esther; Estivill, Xavier; Marti, Eulalia;.

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  Reference:

  Journal Of Clinical Investigation 2016.

• Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTR up-regulation and astrocyte-mediated inflammation

  Miguez A.; Barriga G.; Brito V.; Straccia M.; Giralt A.;

  Ginés S.; Canals J.; Alberch J..

  Reference:

  Human Molecular Genetics 2015.