Pathophysiology and treatment of neurodegenerative disorders
Featured publications
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Conditional BDNF delivery from astrocytes rescues memory deficits, spine density and synaptic properties in the 5xFAD mouse model of Alzheimer disease
de Pins B; Cifuentes-Díaz C; Farah AT; López-Molina L; Montalban E;(...)Delgado-García JM; Alberch J; Gruart A; Girault JA; Giralt A .Reference:Journal Of Neuroscience 2019.
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Regulation of BDNF release by ARMS/Kidins220 through modulation of Synaptotagmin-IV levels.
López-Benito S; Sánchez-Sánchez J; Brito V; Calvo L; Lisa S;(...)Fernández-Fernández S; Bolaños JP; Ginés S; Tessarollo L; Arévalo JC .Reference:Journal Of Neuroscience 2018.
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Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation.
Cariulo C; Azzollini L; Verani M; Martufi P; Boggio R;(...)Santimone I; Squitieri F; Lashuel HA; Petricca L; Caricasole A .Reference:Proceedings Of The National Academy Of Sciences Of The United States Of America 2017.
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7,8 Dihydroxyflavone ameliorates cognitive and motor deficits in a Huntington's disease mouse model through specific activation of the PLCγ1 pathway.
García-Díaz Barriga G; Giralt A; Anglada-Huguet M; Gaja-Capdevila N; Orlandi JG;Soriano J; Canals JM; Alberch J .Reference:Human Molecular Genetics 2017.
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Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model.
Giralt A; Brito V; Chevy Q; Simonnet C; Otsu Y;(...)Coura R; Alberch J; Ginés S; Poncer JC; Girault JA .Reference:Nature Communications 2017.
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Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice
HD iPSC Consortium;Reference:Nature Neuroscience 2017.
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Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons
Mart??n-Ibáñez R; Pardo M; Giralt A; Miguez A; Guardia I;(...)Alberch J; Girault JA; Chan S; Kastner P; Canals JM.Reference:Development 2017.
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Targeting CAG repeat RNAs reduces Huntington's disease phenotype independently of huntingtin levels
Rue, Laura; Banez-Coronel, Monica; Creus-Muncunill, Jordi; Giralt, Albert; Alcala-Vida, Rafael;(...)Aranda, Zeus; Venturi, Veronica; Perez-Navarro, Esther; Estivill, Xavier; Marti, Eulalia;.Reference:Journal Of Clinical Investigation 2016.
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Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTR up-regulation and astrocyte-mediated inflammation
Miguez A.; Barriga G.; Brito V.; Straccia M.; Giralt A.;Ginés S.; Canals J.; Alberch J..Reference:Human Molecular Genetics 2015.