Featured publications

Heterogeneity, crosstalk, and targeting of cancer-associated fibroblasts in cholangiocarcinoma

Vila, PC; Ravichandra, A; Lizaso, AA; Perugorria, MJ; Affo, S;

Reference:
HEPATOLOGY 2024.
Fibroblasts in liver cancer: functions and therapeutic translation

Affo, Silvia; Filliol, Aveline; Gores, Gregory J; Schwabe, Robert F;

Reference:
Lancet Gastroenterology & Hepatology 2023.
Cholangiocarcinoma - novel biological insights and therapeutic strategies

Ilyas, SI; Affo, S; Goyal, L; Lamarca, A; Sapisochin, G;

Yang, JD; Gores, GJ.

Reference:
Nature Reviews Clinical Oncology 2023.
Opposing roles of hepatic stellate cell subpopulations in hepatocarcinogenesis

Filliol, Aveline; Saito, Yoshinobu; Nair, Ajay; Dapito, Dianne H; Yu, Le-Xing;

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Zucman-Rossi, Jessica; Karin, Michael; Henderson, Neil C; Tabas, Ira; Schwabe, Robert F.

Reference:
NATURE 2022.
Cancer-associated fibroblasts in intrahepatic cholangiocarcinoma progression and therapeutic resistance

Ravichandra, Aashreya; Bhattacharjee, Sonakshi; Affo, Silvia;

Reference:
Advances in Cancer Research 2022.
The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver

Mederacke, Ingmar; Filliol, Aveline; Affo, Silvia; Nair, Ajay; Hernandez, Celine;

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Rothlin, Carla, V; Baehre, Heike; Tabas, Ira; Sancho-Bru, Pau; Schwabe, Robert F.

Reference:
Science Translational Medicine 2022.
Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations

Affo, Silvia; Nair, Ajay; Brundu, Francesco; Ravichandra, Aashreya; Bhattacharjee, Sonakshi;

(...)

Seki, Ekihiro; Sia, Daniela; Chen, Xin; Califano, Andrea; Schwabe, Robert F.

Reference:
CANCER CELL 2021.
The Role of Cancer-Associated Fibroblasts and Fibrosisin Liver Cancer

Affo, Silvia; Yu, Le-Xing; Schwabe, Robert F;

Reference:
Annual Review of Pathology-Mechanisms of Disease 2017.