Drs. Francesc Artigas and Analía Bortolozzi, researchers of the team of Neuropharmacology and Experimental Neuropathology in the August Pi i Sunyer Biomedical Research Institute (IDIBAPS) and the IIBB-CSIC, have just published a "Hot Topic" article in the first issue of 2017 in the journal Neuropsychopharmacology, one of the most prestigious in the field of Psychiatry and Neuropharmacology. This section of the journal, published at the beginning of each year, collects significant advances recently produced in the field.
The article briefly reviews the advances made by the group in the development of new experimental strategies for a more rapid and effective treatment of depression through the use of interfering RNA molecules conjugated to serotonin reuptake inhibitors. These advances were published in the journals Molecular Psychiatry and Traslational Psychiatry and show that these conjugates produce an antidepressant effect faster than the conventional drugs in experimental models, which means a remarkable advance with a possible therapeutic application.
Therapeutic Potential of Conjugated siRNAs for the Treatment of Major Depressive Disorder Artigas F, Bortolozzi A. Neuropsychopharmacology. 2017 Jan;42(1):371. doi: 10.1038/npp.2016.182.