Antoni Castells

About me

Featured publications

• Deciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries

  Authors: Fernandez-Rozadilla C, Timofeeva M, Chen Z, Law P, Thomas M, Schmit S, Díez-Obrero V, Hsu L, Fernandez-Tajes J, Palles C, Sherwood K, Briggs S, Svinti V, Donnelly K, Farrington S, Blackmur J, Vaughan-Shaw P, Shu XO, Long J, Cai Q, Guo X, Lu Y, Broderick P, Studd J, Huyghe J, Harrison T, Conti D, Dampier C, Devall M, Schumacher F, Melas M, Rennert G, Obón-Santacana M, Martín-Sánchez V, Moratalla-Navarro F, Oh JH, Kim J, Jee SH, Jung KJ, Kweon SS, Shin MH, Shin A, Ahn YO, Kim DH, Oze I, Wen W, Matsuo K, Matsuda K, Tanikawa C, Ren Z, Gao YT, Jia WH, Hopper J, Jenkins M, Win AK, Pai R, Figueiredo J, Haile R, Gallinger S, Woods M, Newcomb P, Duggan D, Cheadle J, Kaplan R, Maughan T, Kerr R, Kerr D, Kirac I, Böhm J, Mecklin LP, Jousilahti P, Knekt P, Aaltonen L, Rissanen H, Pukkala E, Eriksson J, Cajuso T, Hänninen U, Kondelin J, Palin K, Tanskanen T, Renkonen-Sinisalo L, Zanke B, Männistö S, Albanes D, Weinstein S, Ruiz-Narvaez E, Palmer J, Buchanan D, Platz E, Visvanathan K, Ulrich C, Siegel E, Brezina S, Gsur A, Campbell P, Chang-Claude J, Hoffmeister M, Brenner H, Slattery M, Potter J, Tsilidis K, Schulze M, Gunter M, Murphy N, Castells A, Castellví-Bel S, Moreira L, Arndt V, Shcherbina A, Stern M, Pardamean B, Bishop T, Giles G, Southey M, Idos G, McDonnell K, Abu-Ful Z, Greenson J, Shulman K, Lejbkowicz F, Offit K, Su YR, Steinfelder R, Keku T, van Guelpen B, Hudson T, Hampel H, Pearlman R, Berndt S, Hayes R, Martinez ME, Thomas S, Corley D, Pharoah P, Larsson S, Yen Y, Lenz HJ, White E, Li L, Doheny K, Pugh E, Shelford T, Chan A, Cruz-Correa M, Lindblom A, Hunter D, Joshi A, Schafmayer C, Scacheri P, Kundaje A, Nickerson D, Schoen R, Hampe J, Stadler Z, Vodicka P, Vodickova L, Vymetalkova V, Papadopoulos N, Edlund C, Gauderman W, Thomas D, Shibata D, Toland A, Markowitz S, Kim A, Chanock S, van Duijnhoven F, Feskens E, Sakoda L, Gago-Dominguez M, Wolk A, Naccarati A, Pardini B, FitzGerald L, Lee SC, Ogino S, Bien S, Kooperberg C, Li C, Lin Y, Prentice R, Qu C, Bézieau S, Tangen C, Mardis E, Yamaji T, Sawada N, Iwasaki M, Haiman C, Le Marchand L, Wu A, McNeil C, Coetzee G, Hayward C, Deary I, Harris S, Theodoratou E, Reid S, Walker M, Ooi LY, Moreno V, Casey G, Gruber S, Tomlinson I, Zheng W, Dunlop M, Houlston R, Peters U .

  Reference: Nature Genetics 2023.

• The present and future of gastroenterology and hepatology: an international SWOT analysis (the GASTROSWOT project)

  Authors: de-Madaria E, Mira JJ, Carrillo I, Afif W, Ang D, Antelo M, Bollipo S, Castells A, Chahal P, Heinrich H, Law JK, van Leerdam ME, Lens S, Pannala R, Park SH, Rabiee A, Savarino EV, Singh VK, Vargo J, Charabaty A, Drenth JPH .

  Reference: Lancet Gastroenterology & Hepatology 2022.

• Colon capsule endoscopy versus CT colonography in FIT-positive colorectal cancer screening subjects: a prospective randomised trial-the VICOCA study

  Authors: González-Suárez B, Pagés M, Araujo IK, Romero C, Rodríguez de Miguel C, Ayuso JR, Pozo À, Vila-Casadesús M, Serradesanferm A, Ginès À, Fernández-Esparrach G, Pellisé M, López-Cerón M, Flores D, Córdova H, Sendino O, Grau J, Llach J, Serra-Burriel M, Cárdenas A, Balaguer F, Castells A .

  Reference: Bmc Medicine 2020.

• Eflornithine plus Sulindac for Prevention of Progression in Familial Adenomatous Polyposis

  Authors: Burke CA, Dekker E, Lynch P, Samadder NJ, Balaguer F, Hüneburg R, Burn J, Castells A, Gallinger S, Lim R, Stoffel EM, Gupta S, Henderson A, Kallenberg FG, Kanth P, Roos VH, Ginsberg GG, Sinicrope FA, Strassburg CP, Van Cutsem E, Church J, Lalloo F, Willingham FF, Wise PE, Grady WM, Ford M, Weiss JM, Gryfe R, Rustgi AK, Syngal S, Cohen A .

  Reference: New England Journal Of Medicine 2020.

• White-light Endoscopy is Adequate for Lynch Syndrome Surveillance in a Randomized and Non-inferiority Study

  Authors: Rivero-Sánchez L, Arnau-Collell C, Herrero J, Remedios D, Cubiella J, García-Cougil M, Alvarez V, Albéniz E, Calvo P, Gordillo J, Puig I, López-Vicente J, Huerta A, López-Cerón M, Salces I, Peñas B, Parejo S, Rodriguez de Santiago E, Herraiz M, Carretero C, Gimeno-Garcia AZ, Saperas E, Alvarez-Urturi C, Moreira R, Rodriguez de Miguel C, Ocaña T, Moreira L, Carballal S, Sánchez A, Jung G, Castells A, Llach J, Balaguer F, Pellisé M, EndoCAR group from Spanish Gastroenterology Association (AEG) and Spanish Society of Digestive Endoscopy (SEED).

  Reference: Gastroenterology 2020.

• Identification and validation of microRNA profiles in fecal samples for detection of colorectal cancer

  Authors: Duran-Sanchon S, Moreno L, Augé JM, Serra-Burriel M, Cuatrecasas M, Moreira L, Martín A, Serradesanferm A, Pozo À, Costa R, Lacy A, Pellisé M, Lozano JJ, Gironella M, Castells A .

  Reference: Gastroenterology 2020.

• Risk Stratification for Advanced Colorectal Neoplasia According to Fecal Hemoglobin Concentration in a Colorectal Cancer Screening Program

  Authors: Auge, Josep M; Pellise, Maria; Escudero, Jose M; Hernandez, Cristina; Andreu, Montserrat; Grau, Jaume; Buron, Andrea; Lopez-Ceron, Maria; Bessa, Xavier; Serradesanferm, Anna; Piraces, Merce; Macia, Francesc; Guayta, Rafael; Filella, Xavier; Molina, Rafael; Jimenez, Wladimiro; Castells, Antoni.

  Reference: Gastroenterology 2014.

• Risk of advanced proximal neoplasms according to distal colorectal findings: based strategies

  Authors: Castells, Antoni; Hernandez, Cristina; Grau, Jaume; Serradesanferm, Anna; Pellise, Maria.

  Reference: Journal Of The National Cancer Institute 2013.

• Identification of Lynch Syndrome Among Patients With Colorectal Cancer

  Authors: Moreira, Leticia; Balaguer, Francesc; Lindor, Noralane; de la Chapelle, Albert; Hampel, Heather; Aaltonen, Lauri A; Hopper, John L; Le Marchand, Loic; Gallinger, Steven; Newcomb, Polly A; Haile, Robert; Thibodeau, Stephen N; Gunawardena, Shanaka; Jenkins, Mark A; Buchanan, Daniel D; Potter, John D; Baron, John A; Ahnen, Dennis J; Moreno, Victor; Andreu, Montserrat; de Leon, Maurizio Ponz; Rustgi, Anil K; Castells, Antoni.

  Reference: Jama-Journal Of The American Medical Association 2012.

• Colonoscopy versus fecal immunochemical testing in colorectal-cancer screening

  Authors: Santander Vaquero, Cecilio; Castells, Antoni; Hernandez, Cristina; Grau, Jaume.

  Reference: New England Journal Of Medicine 2012.

Featured Projects

• Identificación de nuevos biomarcadores para la prevención del cáncer colorrectal

  Principal investigator: Antoni Castells Garangou

  Code: AECC_GrupoEstable13

  Duration: 01/10/2013 - 30/09/2019

• Randomized controlled trial of colonoscopy versus fecal immunochemical testing in colorectal cancer screening. The COLONPREV study

  Principal investigator: Antoni Castells Garangou

  Code: AECC_EstClinicos21

  Duration: 01/01/2021 - 30/09/2026

• Deteccion de mirna en heces como nueva estrategia de cribado del cancer colorrectal: identificacion y validacion en poblacion de riesgo medio

  Principal investigator: Antoni Castells Garangou

  Code: MINECO_PE14

  Duration: 01/01/2015 - 31/12/2019

• Caracterización genómica del síndrome de Lynch mediante secuenciación de nueva generación: correlación con el perfil transcriptómico y epigenómico

  Principal investigator: Antoni Castells Garangou

  Code: MICINN_PN10

  Duration: 01/01/2011 - 31/12/2014

• Hipermetilación de la región promotora de los genes MLH1, MGMT, CDKN2A, RASSF1A, CDX1 y SFRP1 en mucosa colorrectal no tumoral como factor favorecedor del desarrollo del cáncer colorrectal

  Principal investigator: Antoni Castells Garangou

  Code: MEC_PN07

  Duration: 02/07/2007 - 31/12/2010