Dolors Colomer

About me

Featured publications

• Systems biology drug screening identifies statins as enhancers of current therapies in chronic lymphocytic leukemia

  Authors:

  Gimenez, Neus; Tripathi, Rupal; Giro, Ariadna; Rosich, Laia; Lopez-Guerra, Monica;

  (...)

  Perez-Galan, Patricia; Delgado, Julio; Campo, Elias; Farres, Judith; Colomer, Dolors.

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  Reference: Scientific Reports 2020.

• Specific NOTCH1 antibody targets DLL4-induced proliferation, migration, and angiogenesis in NOTCH1-mutated CLL cells

  Authors:

  Lopez-Guerra, Monica; Xargay-Torrent, Silvia; Fuentes, Patricia; Roldan, Jocabed; Gonzalez-Farre, Blanca;

  (...)

  Lopez-Guillermo, Armando; Puente, Xose S; Campo, Elias; Toribio, Maria L; Colomer, Dolors.

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  Reference: ONCOGENE 2020.

• Targeting IRAK4 disrupts inflammatory pathways and delays tumor development in chronic lymphocytic leukemia

  Authors:

  Gimenez, Neus; Schulz, Ralph; Higashi, Morihiro; Aymerich, Marta; Villamor, Neus;

  (...)

  Lopez-Guerra, Monica; Campo, Elias; Rosich, Laia; Seiffert, Martina; Colomer, Dolors.

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  Reference: LEUKEMIA 2020.

• Notch1 signaling in NOTCH1-mutated mantle cell lymphoma depends on Delta-Like ligand 4 and is a potential target for specific antibody therapy

  Authors:

  Silkenstedt, Elisabeth; Arenas, Fabian; Colom-Sanmarti, Berta; Xargay-Torrent, Silvia; Higashi, Morihiro;

  (...)

  Bea, Silvia; Toribio, Maria L; Campo, Elias; Lopez-Guerra, Monica; Colomer, Dolors.

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  Reference: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 2019.

• Selective BTK inhibition improves bendamustine therapy response and normalizes immune effector functions in chronic lymphocytic leukemia

  Authors:

  Lee-Verges, Eriong; Hanna, Bola S; Yazdanparast, Haniyeh; Rodriguez, Vanina; Leonor Rodriguez, Marta;

  (...)

  Perez-Galan, Patricia; Lopez-Guerra, Monica; Campo, Elias; Seiffert, Martina; Colomer, Dolors.

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  Reference: INTERNATIONAL JOURNAL OF CANCER 2019.

• Control of chronic lymphocytic leukemia development by clonally-expanded CD8+T-cells that undergo functional exhaustion in secondary lymphoid tissues

  Authors:

  Hanna, Bola S; Roessner, Philipp M; Yazdanparast, Haniyeh; Colomer, Dolors; Campo, Elias;

  (...)

  Stilgenbauer, Stephan; Schmidt, Manfred; Gabriel, Richard; Lichter, Peter; Seiffert, Martina.

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  Reference: LEUKEMIA 2019.

• The Bruton tyrosine kinase inhibitor CC-292 shows activity in mantle cell lymphoma and synergizes with lenalidomide and NIK inhibitors depending on nuclear factor-κB mutational status

  Authors:

  Vidal-Crespo, Anna; Rodriguez, Vanina; Matas-Cespedes, Alba; Lee, Eriong; Rivas-Delgado, Alfredo;

  (...)

  Lopez-Guillermo, Armando; Lopez-Guerra, Monica; Roue, GaeL; Colomer, Dolors; Perez-Galan, Patricia.

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  Reference: HAEMATOLOGICA 2017.

• The Bruton Tyrosine Kinase (BTK) Inhibitor Acalabrutinib Demonstrates Potent On-Target Effects and Efficacy in Two Mouse Models of Chronic Lymphocytic Leukemia.

  Authors:

  Herman, Sarah E M; Montraveta, Arnau; Niemann, Carsten U; Mora-Jensen, Helena; Gulrajani, Michael;

  (...)

  Izumi, Raquel; Johnson, Amy J; Lannutti, Brian J; Wiestner, Adrian; Woyach, Jennifer A.

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  Reference: CLINICAL CANCER RESEARCH 2017.

• The Human CD38 Monoclonal Antibody Daratumumab Shows Antitumor Activity and Hampers Leukemia-Microenvironment Interactions in Chronic Lymphocytic Leukemia

  Authors:

  Matas-Cespedes, Alba; Vidal-Crespo, Anna; Rodriguez, Vanina; Villamor, Neus; Delgado, Julio;

  (...)

  Wiestner, Adrian; Parren, Paul W H I; Doshi, Parul; van Bueren, Jeroen Lammerts; Perez-Galan, Patricia.

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  Reference: CLINICAL CANCER RESEARCH 2017.

• New drug discovery approaches targeting recurrent mutations in chronic lymphocytic leukemia.

  Authors:

  Tripathi, Rupal; Lee-Verges, Eriong; Higashi, Morihiro; Gimenez, Neus; Rosich, Laia;

  Lopez-Guerra, Monica; Colomer, Dolors.

  Reference: Expert Opinion on Drug Discovery 2017.

Featured Projects

• Transpyrenean network of advanced therapies in non-Hodgkin lymphoma - THERAVLINFO (INTERREG-POCTEFA program EFA123/1)

  Principal investigator: Dolors Colomer Pujol

  Duration: 01/01/2024

  Web: http://theravlinfo.eu/

• Nuevos modelos para el estudio de las alteraciones genéticas recurrentes y resistencia a fármacos en la leucemia linfática crónica

  Principal investigator: Dolors Colomer Pujol

  Funder: MINECO

  Code: RTI2018-094584-B-I00

  Duration: 01/08/2019 - 31/12/2021

• Cross border network of personalized immunotherapies in non-Hodgkin lymphoma.

  Principal investigator: Patricia Pérez Galán

  Code: EFA281/16/IMLINFO

  Duration: 01/01/2018 - 31/12/2020

• Dianes terapèutiques i noves tècniques diagnostiques en neoplasies linfoides.

  Principal investigator: Dolors Colomer Pujol

  Code: 2017_SGR_1009

  Duration: 01/01/2018 - 31/12/2019

• neoplasias hematologicas- patologia linfoide

  Principal investigator: Dolors Colomer Pujol

  Code: CB16/12/00334.

  Duration: 01/01/2017