Guillermo Fernández-Varo

Research group

Translational research group in new therapeutic and diagnostic strategies in liver diseases Accredited researcher (R3A-CIBER)

guillermo.fernandez@ciberehd.org 0000-0002-7776-3300

Featured publications

Precision-Cut Liver Slices: A Valuable Preclinical Tool for Translational Research in Liver Fibrosis

Authors:
Perramon, Meritxell; Macias-Herranz, Manuel; Garcia-Perez, Rocio; Jimenez, Wladimiro; Fernandez-Varo, Guillermo;

Reference: International Journal Of Molecular Sciences 2025.
Liver-targeted nanoparticles delivering nitric oxide reduce portal hypertension in cirrhotic rats

Authors:
Perramón, M; Fernández-Varo, G; Moreno-Lanceta, A; Faneca, J; García-Villoria, J;

(...)

Navalón-López, M; López-Moya, M; Fornaguera, C; Borrós, S; García-Pérez, R.

Reference: Biomedicine & Pharmacotherapy 2024.
Partial vasopressin 1a receptor agonism reduces portal hypertension and hyperaldosteronism and induces a powerful diuretic and natriuretic effect in rats with cirrhosis and ascites

Authors:
Fernández-Varo, G; Jiménez, W; Cable, E; Ginès, P; Harris, G;

Bukofzer, S.

Reference: Biomedicine & Pharmacotherapy 2023.
The pituitary tumor-transforming gene 1 / delta like homolog 1 pathway plays a key role in liver fibrogenesis

Authors:
Perramón, M; Carvajal, S; Reichenbach, V; Fernández-Varo, G; Boix, L;

(...)

Melgar-Lesmes, P; Bruix, J; Melmed, S; Lamas, S; Jiménez, W.

Reference: Liver International 2022.
Validation of a Gas Chromatography-Mass Spectrometry Method for the Measurement of the Redox State Metabolic Ratios Lactate/Pyruvate and β-Hydroxybutyrate/Acetoacetate in Biological Samples

Authors:
Wijngaard, Robin; Perramon, Meritxell; Parra-Robert, Marina; Hidalgo, Susana; Butrico, Gina;

(...)

Jimenez, Wladimiro; Fernandez-Varo, Guillermo; Shulman, Gerald I; Cline, Gary W; Casals, Gregori.

Reference: International Journal Of Molecular Sciences 2021.
Bespoken nanoceria: A new effective treatment in experimental hepatocellular carcinoma

Authors:
Fernández-Varo, G; Perramón, M; Carvajal, S; Oró, D; Oller, L;

(...)

Navasa, M; Fuster, J; Garcia-Valdecasas, JC; Pavel, MC; Puntes, V.

Reference: Hepatology 2020.
Cerium oxide nanoparticles display antilipogenic effect in rats with non-alcoholic fatty liver disease

Authors:
Carvajal, S; Perramón, M; Oró, D; Fernández-Varo, G; Casals, G;

(...)

Morales-Ruíz, M; Jiménez, W; Casals, E; Pastor, O; Puntes, V.

Reference: Scientific Reports 2019.
Cerium oxide nanoparticles reduce steatosis, portal hypertension and display antiinflammatory properties in rats with liver fibrosis

Authors:
Oro, Denise; Yudina, Tetyana; Fernandez-Varo, Guillermo; Casals, Eudald; Reichenbach, Vedrana;

(...)

Gonzalez de la Presa, Bernardino; Sandalinas, Silvia; Carvajal, Silvia; Puntes, Victor; Jimenez, Wladimiro.

Reference: Journal Of Hepatology 2016.
Vasopressin 1a receptor partial agonism increases sodium excretion and reduces portal hypertension and ascites in cirrhotic rats

Authors:
Fernandez-Varo, Guillermo; Oro, Denise; Earl Cable, Edward; Reichenbach, Vedrana; Carvajal, Silvia;

Gonzalez de la Presa, Bernardino; Wisniewski, Kazimierz; Gines, Pere; Harris, Geoffrey; Jimenez, Wladimiro.

Reference: Hepatology 2016.
Adenoviral dominant-negative soluble PDGFRbeta improves hepatic collagen, systemic hemodynamics, and portal pressure in fibrotic rats

Authors:
Reichenbach, V; Fernandez-Varo, G; Casals, G; Oro, D; Ros, J;

Melgar-Lesmes, P; Weiskirchen, R; Morales-Ruiz, M; Jimenez, W.

Reference: Journal Of Hepatology 2012.

Featured Projects

THERANANO: Determining the therapeutic use in liver diseases of advanced antioxidant conjugates based on cerium oxide nanoparticles

Principal investigator: Gregori Casals Mercadal, Guillermo Fernandez Varo

Funder: Subdireccion General de Evaluacion y Fomento de la Investigacion

Code: PI19/00774

Duration: 01/01/2020 - 30/06/2024
Desarrollo y aplicación de nanopartículas de cerio en el tratamiento del carcinoma hepatocelular.

Principal investigator: Wladimiro Jimenez, Guillermo Fernandez Varo

Funder: AGAUR-FEDER. Convocatoria de ayudas de Indústria del Coneixement 2018, PRODUCTE.

Code: 2018-PROD-00187

Duration: 01/04/2018 - 31/01/2021
Utilidad terapéutica de las nanopartículas de óxido de cerio en las enfermedades hepáticas.

Principal investigator: Wladimiro Jimenez Povedano, Guillermo Fernandez Varo

Funder: Ministerio de Economía y Competitividad. SAF2015-64126-R

Code: SAF2015-64126-R

Duration: 01/01/2016 - 31/12/2018

Guillermo Fernández-Varo

Research group

Featured publications

Featured Projects

THERANANO: Determining the therapeutic use in liver diseases of advanced antioxidant conjugates based on cerium oxide nanoparticles

Desarrollo y aplicación de nanopartículas de cerio en el tratamiento del carcinoma hepatocelular.

Utilidad terapéutica de las nanopartículas de óxido de cerio en las enfermedades hepáticas.

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