Isaac Almendros

About me

Featured publications

• Effects of aging on the biomechanical properties of the lung extracellular matrix: dependence on tissular stretch

  Authors:

  Ulldemolins, Anna; Narciso, Maria; Sanz-Fraile, Hector; Otero, Jorge; Farre, Ramon;

  Gavara, Nuria; Almendros, Isaac.

  Reference: Frontiers In Cell And Developmental Biology 2024.

• Low-cost, open-source device for simultaneously subjecting rodents to different circadian cycles of light, food, and temperature.

  Authors:

  Farre, Ramon; Rodriguez-Lazaro, Miguel A; Otero, Jorge; Gavara, Nuria; Sunyer, Raimon;

  Farre, Nuria; Gozal, David; Almendros, Isaac.

  Reference: Frontiers In Physiology 2024.

• Lung Micrometastases Display ECM Depletion and Softening While Macrometastases Are 30-Fold Stiffer and Enriched in Fibronectin

  Authors:

  Narciso, Maria; Martinez, Africa; Junior, Constanca; Diaz-Valdivia, Natalia; Ulldemolins, Anna;

  (...)

  Navajas, Daniel; Farre, Ramon; Alcaraz, Jordi; Almendros, Isaac; Gavara, Nuria.

  See complete list of authors

  Reference: Cancers 2023.

• Lung Extracellular Matrix Hydrogels-Derived Vesicles Contribute to Epithelial Lung Repair

  Authors:

  Ulldemolins, Anna; Jurado, Alicia; Herranz-Diez, Carolina; Gavara, Nuria; Otero, Jorge;

  Farre, Ramon; Almendros, Isaac.

  Reference: Polymers 2022.

• Novel Decellularization Method for Tissue Slices

  Authors:

  Narciso, Maria; Ulldemolins, Anna; Junior, Constanca; Otero, Jorge; Navajas, Daniel;

  Farre, Ramon; Gavara, Nuria; Almendros, Isaac.

  Reference: Frontiers In Bioengineering And Biotechnology 2022.

• Metabolic dysfunction in OSA: Is there something new under the sun?

  Authors:

  Almendros, Isaac; Basoglu, Ozen K; Conde, Silvia V; Liguori, Claudio; Saaresranta, Tarja;

  Reference: Journal Of Sleep Research 2022.

• Human experimental models: Seeking to enhance multiscale research in sleep apnoea

  Authors:

  Farre, Ramon; Gozal, David; Almendros, Isaac;

  Reference: European Respiratory Journal 2021.

• Oxygen Biosensors and Control in 3D Physiomimetic Experimental Models

  Authors:

  Otero, Jorge; Ulldemolins, Anna; Farre, Ramon; Almendros, Isaac;

  Reference: Antioxidants 2021.

• The force loading rate drives cell mechanosensing through both reinforcement and cytoskeletal softening

  Authors:

  Andreu, Ion; Falcones, Bryan; Hurst, Sebastian; Chahare, Nimesh; Quiroga, Xarxa;

  (...)

  Trepat, Xavier; Farre, Ramon; Betz, Timo; Almendros, Isaac; Roca-Cusachs, Pere.

  See complete list of authors

  Reference: Nature Communications 2021.

• Experimental Setting for Applying Mechanical Stimuli to Study the Endothelial Response of Ex Vivo Vessels under Realistic Pathophysiological Environments

  Authors:

  Osuna, Ana; Ulldemolins, Anna; Sanz-Fraile, Hector; Otero, Jorge; Farre, Nuria;

  Farre, Ramon; Almendros, Isaac.

  Reference: Life 2021.

Featured Projects

• Clinical, translational and experimental study about OSA influence on the persistence of thrombi after PE. NIX-Extention Study

  Principal investigator: Isaac Almendros

  Funder: Sociedad Española de Neumología y Cirugía Torácica SEPAR

  Duration: 01/01/2024

• Mechanisms driving the end-organ noxius effects of intermittent hypoxia using a novel ex vivo physiomimetic model based on precision-cut tissue slices

  Principal investigator: Isaac Almendros

  Funder: Ministerio de Ciencia, Innovación y Universidades

  Code: PID2022-140774OB-I00

  Duration: 01/09/2023 - 01/09/2026

• Effect of intermittent hypoxia/hypercapnia on a new ex vivo model of brain, liver, heart, and kidney tissue in comorbidity models of sleep apnea

  Principal investigator: Isaac Almendros

  Funder: Sociedad Española de Neumología y Cirugía Torácica SEPAR

  Code: 1396/2022

  Duration: 01/01/2023

• Bioenginyeria multiescala en processos fisiopatològics (BIOPAT)

  Principal investigator: Isaac Almendros

  Funder: AGAUR

  Code: SGR 00523

  Duration: 01/01/2022

• Pulmonary Extracellular Matrix Hydrogels for Preconditioning and Instillation of Mesenchymal Stem Cells in the Treatment of Severe Respiratory Diseases

  Principal investigator: Isaac Almendros

  Funder: Ministerio de Ciencia, Innovación y Universidades

  Code: PID2019-108958RB-I00

  Duration: 01/01/2020