Jordi Alberch

Research group

Pathophysiology and treatment of neurodegenerative disorders Group leader (R4-UB)

alberch@ub.edu 0000-0002-8684-2721

Featured publications

Conditional BDNF delivery from astrocytes rescues memory deficits, spine density and synaptic properties in the 5xFAD mouse model of Alzheimer disease

Authors: de Pins B, Cifuentes-Díaz C, Farah AT, López-Molina L, Montalban E, Sancho-Balsells A, López A, Ginés S, Delgado-García JM, Alberch J, Gruart A, Girault JA, Giralt A .

Reference: Journal Of Neuroscience 2019.
7,8 Dihydroxyflavone ameliorates cognitive and motor deficits in a Huntington's disease mouse model through specific activation of the PLCγ1 pathway.

Authors: García-Díaz Barriga G, Giralt A, Anglada-Huguet M, Gaja-Capdevila N, Orlandi JG, Soriano J, Canals JM, Alberch J .

Reference: Human Molecular Genetics 2017.
Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model.

Authors: Giralt A, Brito V, Chevy Q, Simonnet C, Otsu Y, Cifuentes-Díaz C, de Pins B, Coura R, Alberch J, Ginés S, Poncer JC, Girault JA .

Reference: Nature Communications 2017.
Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice

Authors: HD iPSC Consortium.

Reference: Nature Neuroscience 2017.
Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons

Authors: Mart??n-Ibáñez R; Pardo M; Giralt A; Miguez A; Guardia I; Marion-Poll L; Herranz C; Esgleas M; Barriga GGD; Edel MJ; Vicario-Abejón C; Alberch J; Girault JA; Chan S; Kastner P; Canals JM.

Reference: Development 2017.
Prostaglandin E2 EP2 activation reduces memory decline in R6/1 mouse model of Huntington's disease by the induction of BDNF-dependent synaptic plasticity

Authors: Anglada-Huguet M, Vidal-Sancho L, Giralt A, García-Díaz Barriga G, Xifró X, Alberch J .

Reference: Neurobiology Of Disease 2016.
Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTR up-regulation and astrocyte-mediated inflammation

Authors: Miguez A., Barriga G., Brito V., Straccia M., Giralt A., Ginés S., Canals J., Alberch J..

Reference: Human Molecular Genetics 2015.
Neurotrophin receptor p75NTR mediates Huntington''s disease-associated synaptic and memory dysfunction

Authors: Alberch Vie, Jordi; Brito, V; Giralt, A; Enriquez-Barreto, L; Puigdellivol, M; Suelves, N; Zamora-Moratalla, A; Ballesteros, JJ; Martin, ED; Dominguez-Iturza, N; Morales, M; Alberch, J; Gines, S.

Reference: Journal Of Clinical Investigation 2014.
Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models

Authors: Alberch Vie, Jordi; Marco, Sonia; Giralt, Albert; Petrovic, Milos M; Pouladi, Mahmoud A; Martinez-Turrillas, Rebeca; Martinez-Hernndez, Jose; Kaltenbach, Linda S; Torres-Peraza, Jesus; Graham, Rona K; Watanabe, Masahiko; Lujan, Rafael; Nakanishi, Nobuki; Lipton, Stuart A; Lo, Donald C; Hayden, Michael R; Alberch, Jordi; Wesseling, John F; Perez-Otano, Isabel.

Reference: Nature Medicine 2013.

Featured Projects

Institut de Neurociències de la Universitat de Barcelona (UBNEURO)

Principal investigator: Jordi Alberch Vie

Funder: Universitat de Barcelona (Sede); Ministerio de Economía, Industria y Competitividad ; Universitat de Barcelona (Participante)

Duration: 01/07/2018 - 30/06/2022
Identification of chorein function in neurodegeneration of the basal ganglia for developing new therapeutical approaches in Chorea-Acanthocytosis

Principal investigator: Jordi Alberch Vie

Code: 309965

Duration: 01/07/2018
Modulación de la dinámica de las redes neuronales como estrategia terapéutica para recuperar la disfunción de los ganglios basales en las enfermedades del movimiento

Principal investigator: Manuel Jose Rodriguez Allue

Code: SAF2017-88076-R

Duration: 01/01/2018 - 31/12/2020
European Training Network for Cell-based Regenerative Medicine (Training4CRM)

Code: 722779

Duration: 01/11/2016 - 31/10/2020
Custom architecturally defined 3D stem cell derived functional human neural networks for transformative progress in neuroscience and medicine (MESO_BRAIN)

Code: 713140

Duration: 01/09/2016 - 31/08/2019

Jordi Alberch

Research group

Featured publications

Featured Projects

Institut de Neurociències de la Universitat de Barcelona (UBNEURO)

Identification of chorein function in neurodegeneration of the basal ganglia for developing new therapeutical approaches in Chorea-Acanthocytosis

Modulación de la dinámica de las redes neuronales como estrategia terapéutica para recuperar la disfunción de los ganglios basales en las enfermedades del movimiento

European Training Network for Cell-based Regenerative Medicine (Training4CRM)

Custom architecturally defined 3D stem cell derived functional human neural networks for transformative progress in neuroscience and medicine (MESO_BRAIN)

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