
Jordi Alberch
Research group
- Pathophysiology and treatment of neurodegenerative disorders Group leader (R4-UB)
Featured publications
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Conditional BDNF delivery from astrocytes rescues memory deficits, spine density and synaptic properties in the 5xFAD mouse model of Alzheimer disease
Authors: de Pins B, Cifuentes-Díaz C, Farah AT, López-Molina L, Montalban E, Sancho-Balsells A, López A, Ginés S, Delgado-García JM, Alberch J, Gruart A, Girault JA, Giralt A .Reference: Journal Of Neuroscience 2019. -
7,8 Dihydroxyflavone ameliorates cognitive and motor deficits in a Huntington's disease mouse model through specific activation of the PLCγ1 pathway.
Authors: García-Díaz Barriga G, Giralt A, Anglada-Huguet M, Gaja-Capdevila N, Orlandi JG, Soriano J, Canals JM, Alberch J .Reference: Human Molecular Genetics 2017. -
Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model.
Authors: Giralt A, Brito V, Chevy Q, Simonnet C, Otsu Y, Cifuentes-Díaz C, de Pins B, Coura R, Alberch J, Ginés S, Poncer JC, Girault JA .Reference: Nature Communications 2017. -
Developmental alterations in Huntington's disease neural cells and pharmacological rescue in cells and mice
Authors: HD iPSC Consortium.Reference: Nature Neuroscience 2017. -
Helios expression coordinates the development of a subset of striatopallidal medium spiny neurons
Authors: Mart??n-Ibáñez R; Pardo M; Giralt A; Miguez A; Guardia I; Marion-Poll L; Herranz C; Esgleas M; Barriga GGD; Edel MJ; Vicario-Abejón C; Alberch J; Girault JA; Chan S; Kastner P; Canals JM.Reference: Development 2017. -
Prostaglandin E2 EP2 activation reduces memory decline in R6/1 mouse model of Huntington's disease by the induction of BDNF-dependent synaptic plasticity
Authors: Anglada-Huguet M, Vidal-Sancho L, Giralt A, García-Díaz Barriga G, Xifró X, Alberch J .Reference: Neurobiology Of Disease 2016. -
Fingolimod (FTY720) enhances hippocampal synaptic plasticity and memory in Huntington's disease by preventing p75NTR up-regulation and astrocyte-mediated inflammation
Authors: Miguez A., Barriga G., Brito V., Straccia M., Giralt A., Ginés S., Canals J., Alberch J..Reference: Human Molecular Genetics 2015. -
Neurotrophin receptor p75NTR mediates Huntington''s disease-associated synaptic and memory dysfunction
Authors: Alberch Vie, Jordi; Brito, V; Giralt, A; Enriquez-Barreto, L; Puigdellivol, M; Suelves, N; Zamora-Moratalla, A; Ballesteros, JJ; Martin, ED; Dominguez-Iturza, N; Morales, M; Alberch, J; Gines, S.Reference: Journal Of Clinical Investigation 2014. -
Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models
Authors: Alberch Vie, Jordi; Marco, Sonia; Giralt, Albert; Petrovic, Milos M; Pouladi, Mahmoud A; Martinez-Turrillas, Rebeca; Martinez-Hernndez, Jose; Kaltenbach, Linda S; Torres-Peraza, Jesus; Graham, Rona K; Watanabe, Masahiko; Lujan, Rafael; Nakanishi, Nobuki; Lipton, Stuart A; Lo, Donald C; Hayden, Michael R; Alberch, Jordi; Wesseling, John F; Perez-Otano, Isabel.Reference: Nature Medicine 2013.
Featured Projects
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Institut de Neurociències de la Universitat de Barcelona (UBNEURO)
Principal investigator: Jordi Alberch VieFunder: Universitat de Barcelona (Sede); Ministerio de Economía, Industria y Competitividad ; Universitat de Barcelona (Participante)Duration: 01/07/2018 - 30/06/2022 -
Identification of chorein function in neurodegeneration of the basal ganglia for developing new therapeutical approaches in Chorea-Acanthocytosis
Principal investigator: Jordi Alberch VieCode: 309965Duration: 01/07/2018 -
Modulación de la dinámica de las redes neuronales como estrategia terapéutica para recuperar la disfunción de los ganglios basales en las enfermedades del movimiento
Principal investigator: Manuel Jose Rodriguez AllueCode: SAF2017-88076-RDuration: 01/01/2018 - 31/12/2020 -
European Training Network for Cell-based Regenerative Medicine (Training4CRM)
Code: 722779Duration: 01/11/2016 - 31/10/2020 -
Custom architecturally defined 3D stem cell derived functional human neural networks for transformative progress in neuroscience and medicine (MESO_BRAIN)
Code: 713140Duration: 01/09/2016 - 31/08/2019