Jordi Gracia-Sancho

Research group

Liver vascular biology Group leader (R4)

jgracia@recerca.clinic.cat 0000-0001-7736-4089

Featured publications

Increased sinusoidal pressure impairs liver endothelial mechanosensing, uncovering novel biomarkers of portal hypertension

Authors:
Ortega-Ribera, M; Gibert-Ramos, A; Abad-Jordà, L; Magaz, M; Pastó, R;

(...)

Paule, L; Lozano, JJ; Albilios, A; Castillo, E; Villa, R.

Reference: Jhep Rep 2023.
Serum miR-181b-5p predicts ascites onset in patients with compensated cirrhosis

Authors:
Garcia de Paredes, Ana Garcia; Villanueva, Candid; Blanco, Carolina; Genesca, Joan; Manicardi, Nicolo;

(...)

Manuel Falcon-Perez, Juan; Banares, Rafael; Bosch, Jaime; Gracia-Sancho, Jordi; Albillos, Agustin.

Reference: Jhep Rep 2021.
Impact of Aging on Liver Cells and Liver Disease: Focus on the Biliary and Vascular Compartments

Authors:
Baiocchi, L; Glaser, S; Francis, H; Kennedy, L; Alpini, G;

Gracia-Sancho, J; Felli, E.

Reference: Hepatol Commun 2021.
Transcriptomic profiling of liver sinusoidal endothelial cells during cirrhosis progression reveals stage-specific secretory signature

Authors:
Manicardi, N; Iglesias, AF; Abad, L; Ribera, MO; Martinez-Alcocer, A;

(...)

Falcon-Perez, J; Azkargorta, M; Elortza, F; Bosch, J; Cubero, FJ.

Reference: Journal Of Hepatology 2021.
Transcriptomic profiling of the liver sinusoidal endothelium during cirrhosis reveals stage-specific secretory signature

Authors:
Manicardi, N; Fernández-Iglesias, A; Abad-Jordà, L; Ortega-Ribera, M; Sanfeliu-Redondo, D;

(...)

Albillos, A; Vaquero, J; Falcón-Pérez, JM; Azkargorta, M; Elortza, F.

Reference: Cancers 2021.
Role of liver sinusoidal endothelial cells in liver diseases

Authors:
Gracia-Sancho, J; Fernández-Iglesias, A; Caparrós, E; Francés, R;

Reference: Nature Reviews Gastroenterology & Hepatology 2021.
Pan-PPAR agonist lanifibranor improves portal hypertension and hepatic fibrosis in experimental advanced chronic liver disease

Authors:
Boyer-Diaz, Z; Aristu-Zabalza, P; Andrés-Rozas, M; Gracia-Sancho, J; Robert, C;

(...)

Junien, JL; Wettstein, G; Ortega-Ribera, M; Fernández-Iglesias, A; Bosch, J.

Reference: Journal Of Hepatology 2021.
Regression of portal hypertension: underlying mechanisms and therapeutic strategies

Authors:
Selicean, S; Wang, C; Guixé-Muntet, S; Gracia-Sancho, J; Stefanescu, H;

Kawada, N.

Reference: Hepatology International 2021.
Novel therapeutics for portal hypertension and fibrosis in chronic liver disease

Authors:
Guixe-Muntet, Sergi; Zhu, Chang-Peng; Xie, Wei-Fen; Gracia-Sancho, Jordi;

Reference: Pharmacology & Therapeutics 2020.
Nuclear deformation mediates liver cell mechanosensing in cirrhosis

Authors:
Guixe-Muntet, Sergi; Ortega-Ribera, Marti; Wang, Cong; Selicean, Sonia; Andreu, Ion;

(...)

Roca-Cusachs, Pere; Dufour, Jean-Francois; Bosch, Jaime; Berzigotti, Annalisa; Gracia-Sancho, Jordi.

Reference: Jhep Rep 2020.

Featured Projects

FIS PI20/00220. Impact of sinusoidal hypertension on the pathophysiology of liver diseases: depicting novel mechanisms and therapeutic opportunities

Principal investigator: Jordi GRACIA SANCHO

Funder: Instituto de Salud Carlos (III)

Duration: 01/01/2021 - 31/12/2023
Capillarization of the liver sinusoidal endothelium in cirrhosis: global characterization for the discovery of new therapeutic targets.

Principal investigator: Jordi GRACIA SANCHO

Funder: Instituto de Salud Carlos III

Code: PI17/00012

Duration: 01/01/2018 - 31/12/2020
Exosomes in liver diseases

Funder: Instituto de Salud Carlos III

Duration: 01/11/2016 - 31/10/2018
Capillarization of the liver sinusoidal endothelium: Orchestration by miRNAs

Principal investigator: Jorge Sergio Gracia Sancho

Funder: Gilead International Research Scholars in Liver Diseases

Code: GILEAD_IRS_16_02

Duration: 01/06/2016 - 01/06/2018
Pre-clinical Validation of a Novel Protein Drug Candidate for ASH and NASH Treatment

Code: 1R01DK126080-01A1

Duration: 01/10/2021 - 30/09/2024

Jordi Gracia-Sancho

Research group

Featured publications

Serum miR-181b-5p predicts ascites onset in patients with compensated cirrhosis

Transcriptomic profiling of liver sinusoidal endothelial cells during cirrhosis progression reveals stage-specific secretory signature

Featured Projects

FIS PI20/00220. Impact of sinusoidal hypertension on the pathophysiology of liver diseases: depicting novel mechanisms and therapeutic opportunities

Capillarization of the liver sinusoidal endothelium in cirrhosis: global characterization for the discovery of new therapeutic targets.

Exosomes in liver diseases

Capillarization of the liver sinusoidal endothelium: Orchestration by miRNAs

Pre-clinical Validation of a Novel Protein Drug Candidate for ASH and NASH Treatment

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