About me

Dr. Martin-Subero graduated from the University of Navarra (Spain) with a degree in Biochemistry. In 2001, he completed a PhD with honours as a joined effort between the University of Navarra and the Christian-Albrechts University of Kiel (Germany). He continued his postdoctoral training at the Christian-Albrechts University. Upon returning to Spain in 2009, he started to coordinate a research group on epigenomics at the University of Barcelona. In 2016, he was appointed leader of the Biomedical Epigenomics group at the IDIBAPS research institute in Barcelona, and in 2018 he was awarded with an ICREA Research Professorship. He has published over 200 peer-reviewed articles.

Featured publications

  • Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics

    Authors: Speedy HE, Beekman R, Chapaprieta V, Orlando G, Law PJ, Martín-García D, Gutiérrez-Abril J, Catovsky D, Beà S, Clot G, Puiggròs M, Torrents D, Puente XS, Allan JM, López-Otín C, Campo E, Houlston RS, Martín-Subero JI .
    Reference: Nature Communications 2019.
  • Insight into origins, mechanisms & utility of DNA methylation in B cell malignancies.

    Authors: Oakes CC; Martin-Subero JI.
    Reference: Blood 2018.
  • Charting the dynamic epigenome during B-cell development

    Authors: Martin-Subero J; Oakes C.
    Reference: Seminars In Cancer Biology 2018.
  • The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemia

    Authors: Beekman R, Chapaprieta V, Russiñol N, Vilarrasa-Blasi R, Verdaguer-Dot N, Martens JHA, Duran-Ferrer M, Kulis M, Serra F, Javierre BM, Wingett SW, Clot G, Queirós AC, Castellano G, Blanc J, Gut M, Merkel A, Heath S, Vlasova A, Ullrich S, Palumbo E, Enjuanes A, Martín-García D, Beà S, Pinyol M, Aymerich M, Royo R, Puiggros M, Torrents D, Datta A, Lowy E, Kostadima M, Roller M, Clarke L, Flicek P, Agirre X, Prosper F, Baumann T, Delgado J, López-Guillermo A, Fraser P, Yaspo ML, Guigó R, Siebert R, Martí-Renom MA, Puente XS, López-Otín C, Gut I, Stunnenberg HG, Campo E, Martin-Subero JI .
    Reference: Nature Medicine 2018.
  • Decoding the DNA Methylome of Mantle Cell Lymphoma in the Light of the Entire B Cell Lineage

    Authors: Queiros, Ana C.; Beekman, Renee; Vilarrasa-Blasi, Roser; Duran-Ferrer, Marti; Clot, Guillem; Merkel, Angelika; Raineri, Emanuele; Russinol, Nuria; Castellano, Giancarlo; Bea, Silvia; Navarro, Alba; Kulis, Marta; Verdaguer-Dot, Nuria; Jares, Pedro; Enjuanes, Anna; Jose Calasanz, Maria; Bergmann, Anke; Vater, Inga; Salaverria, Itziar; van de Werken, Harmen J. G.; Wilson, Wyndham H.; Datta, Avik; Flicek, Paul; Royo, Romina; Martens, Joost; Gine, Eva; Lopez-Guillermo, Armando; Stunnenberg, Hendrik G.; Klapper, Wolfram; Pott, Christiane; Heath, Simon; Gut, Ivo G.; Siebert, Reiner; Campo, Elias; Martin-Subero, Jose I.;.
    Reference: Cancer Cell 2016.
  • Whole-genome fingerprint of the DNA methylome during human B cell differentiation

    Authors: Kulis, Marta; Merkel, Angelika; Heath, Simon; Queiros, Ana C.; Schuyler, Ronald P.; Castellano, Giancarlo; Beekman, Renee; Raineri, Emanuele; Esteve, Anna; Clot, Guillem; Verdaguer-Dot, Nuria; Duran-Ferrer, Marti; Russinol, Nuria; Vilarrasa-Blasi, Roser; Ecker, Simone; Pancaldi, Vera; Rico, Daniel; Agueda, Lidia; Blanc, Julie; Richardson, David; Clarke, Laura; Datta, Avik; Pascual, Marien; Agirre, Xabier; Prosper, Felipe; Alignani, Diego; Paiva, Bruno; Caron, Gersende; Fest, Thierry; Muench, Marcus O.; Fomin, Marina E.; Lee, Seung-Tae; Wiemels, Joseph L.; Valencia, Alfonso; Gut, Marta; Flicek, Paul; Stunnenberg, Hendrik G.; Siebert, Reiner; Kueppers, Ralf; Gut, Ivo G.; Campo, Elias; Martin-Subero, Jose I.;.
    Reference: Nature Genetics 2015.
  • Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers

    Authors: Agirre, Xabier; Castellano, Giancarlo; Pascual, Marien; Heath, Simon; Kulis, Marta; Segura, Victor; Bergmann, Anke; Esteve, Anna; Merkel, Angelika; Raineri, Emanuele; Agueda, Lidia; Blanc, Julie; Richardson, David; Clarke, Laura; Datta, Avik; Russinol, Nuria; Queiros, Ana C.; Beekman, Renee; Rodriguez-Madoz, Juan R.; San Jose-Eneriz, Edurne; Fang, Fang; Gutierrez, Norma C.; Garcia-Verdugo, Jose M.; Robson, Michael I.; Schirmer, Eric C.; Guruceaga, Elisabeth; Martens, Joost H. A.; Gut, Marta; Calasanz, Maria J.; Flicek, Paul; Siebert, Reiner; Campo, Elias; San Miguel, Jesus F.; Melnick, Ari; Stunnenberg, Hendrik G.; Gut, Ivo G.; Prosper, Felipe; Martin-Subero, Jose I.;.
    Reference: Genome Research 2015.
  • A B-cell epigenetic signature defines three biologic subgroups of chronic lymphocytic leukemia with clinical impact

    Authors: Queirós A., Villamor N., Clot G., Martinez-Trillos A., Kulis M., Navarro A., Penas E., Jayne S., Majid A., Richter J., Bergmann A., Kolarova J., Royo C., Russiñol N., Castellano G., Pinyol M., Bea S., Salaverria I., López-Guerra M., Colomer D., Aymerich M., Rozman M., Delgado J., Giné E., González-Díaz M., Puente X., Siebert R., Dyer M., López-Otín C., Rozman C., Campo E., López-Guillermo A., Martín-Subero J..
    Reference: Leukemia 2015.
  • Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia

    Authors: Kulis, Marta; Heath, Simon; Bibikova, Marina; Queiros, Ana C; Navarro, Alba; Clot, Guillem; Castellano, Giancarlo; Brun-Heath, Isabelle; Pinyol, Magda; Barberan-Soler, Sergio; Papasaikas, Panagiotis; Jares, Pedro; Bea, Silvia; Rico, Daniel; Ecker, Simone; Rubio, Miriam; Royo, Romina; Ho, Vincent; Klotzle, Brandy; Hernandez, Lluis; Conde, Laura; Lopez-Guerra, Monica; Colomer, Dolors; Villamor, Neus; Aymerich, Marta; Rozman, Maria; Bayes, Monica; Gut, Marta; Gelpi, Josep L; Orozco, Modesto; Fan, Jian-Bing; Quesada, Victor; Puente, Xose S; Pisano, David G; Valencia, Alfonso; Lopez-Guillermo, Armando; Gut, Ivo; Lopez-Otin, Carlos; Campo, Elias; Martin-Subero, Jose I.
    Reference: Nature Genetics 2012.

Featured Projects

  • Deciphering the pathogenetic and clinical role of aberrant DNA methylation of enhancer elements in chronic lymphocytic leukemia

    Principal investigator: José Ignacio Martín Subero
    Funder: World Cancer Research Fund International
    Code: 16-1285
    Duration: 01/07/2016 - 30/06/2019
  • Functional and clinical impact of enhancer DNA methylation in mantle cell lymphoma

    Principal investigator: José Ignacio Martín Subero
    Funder: European Hematology Association (EHA)
    Code: INT_EHA_Fellow13sept
    Duration: 16/11/2014 - 15/11/2017
  • Análisi del (hidroxi)metiloma sencer de I'ADN i del transcriptoma en el Mieloma Múltiple

    Principal investigator: José Ignacio Martín Subero
    Funder: Fundació La Marató de TV3
    Code: 20132130
    Duration: 01/01/2014 - 01/01/2017
  • A BLUEPRINT of Haematopoietic Epigenomes

    Principal investigator: José Ignacio Martín Subero
    Funder: European Commission
    Code: HEALTH-F5-2011-282510
    Duration: 01/10/2011 - 30/09/2017
  • Caracterización epigenómica de las neoplasias hematológicas

    Principal investigator: José Ignacio Martín Subero
    Funder: Ministerio de Educación y Ciencia (MEC)
    Code: SAF2009-08663
    Duration: 10/11/2010 - 31/12/2012