
Thomas Walle
Research group
- Computational cancer biomedicine Junior group leader (R3B)
About me
My research has uncovered how the immune system’s circulating cells are linked to cancer progression and treatment success. By combining clinical studies with computational biology, I helped explain how Natural Killer cells and inflammatory signals shape radiotherapy outcomes and identified T cell states that seem to predict immunotherapy response across multiple cancers. I have developed widely used computational tools in the single cell genomics space such as Spectra, Cytopus, Compocyte, and Suco that have advanced immune profiling. These approaches were first implemented in my prospective ANTICIPATE clinical study, pioneering single-cell genomics in a clinical setting and establishing the basis for our current work on systemic immunity in cancer
Featured publications
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Photon and particle radiotherapy induce redundant modular chemotaxis of human lymphocytes
Authors:Reference: Jci Insight 2025. -
Supervised discovery of interpretable gene programs from single-cell data
Authors:Reference: Nature Biotechnology 2024. -
Epigenetic plasticity cooperates with cell-cell interactions to direct pancreatic tumorigenesis.
Authors:Reference: Science 2023. -
Cytokine release syndrome-like serum responses after COVID-19 vaccination are frequent and clinically inapparent under cancer immunotherapy
Authors:Reference: Nature Cancer 2022. -
Radiotherapy orchestrates natural killer cell dependent antitumor immune responses through CXCL8
Authors:Reference: Science Advances 2022. -
Immune profiling of human tumors identifies CD73 as a combinatorial target in glioblastoma
Authors:Reference: Nature Medicine 2020.