Líneas de investigación

• 1. Translational research devoted to genomic profiling, assessing mutations and copy number alterations (panels, exome, and, in some cases, whole genome) of lymphoproliferative disorders

  Directed by Armando López-Guillermo. 

  Assessment of mutations and copy number alterations (exome and whole genome in some cases) of main lymphomas, including chronic lymphocytic leukemia (CLL), mantle-cell lymphomas (MCL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL) and splenic marginal zone lymphomas (SMZL). 

• 2. Translational research devoted to study the cellular microenvironment in FL, CLL and other lymphomas

  Directed by Laura Magnano.

  Microenvironment has demonstrated to be critical in the development of lymphomas, as well as the prognosis and the response to therapies, particularly to immunomodulators and small molecules with targeted action. In collaboration with other groups of IDIBAPS, we have a line of research to assess the microenvironment with pre-clinical and clinical models of response to specific treatments. 

• 3. Epidemiological and prognostic studies based on clinical variables and biomarkers linked to the biology of lymphomas

  Directed by Eva Giné.

  We have participated in several international initiatives to develop prognostic scores based in both clinical variables and biomarkers more related to the biology of the different lymphomas. Among other histologies, clinico-biological studies were particularly developed in MCL. 

• 4. New therapies in lymphoproliferative disorders, including developing and performing clinical trials with experimental targeted therapies

  Directed by Julio Delgado.

  Clinical research with new drugs from academic and pharma trials. Of note is the use of an academic CD-19 CAR- T cell developed in our institution, with clinical trials for acute lymphoblastic leukemia, CD19+ lymphoproliferative disorders and multiple myeloma.