Publicaciones destacadas

Blood multiomics reveal a dysregulated lipid mediator-mitochondrial network associated with the outcome of advanced cirrhosis.

López-Vicario C; Aguilar F; Chapus F; de la Peña-Ramirez C; Fenaille F;

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Titos E; Moreau R; Arroyo V; Rautou PE; Clària J.

Referencia:
Nature Communications 2026.
The linoleic acid-derived leukotoxin 9,10-DiHOME drives immunosuppression in patients with acute-on-chronic liver failure.

Contreras BJ; Romero-Grimaldo B; Sánchez-Rodríguez MB; Casulleras M; Duran-Güell M;

Papp M; Moreau R; Trebicka J; Clària J; López-Vicario C;.

Referencia:
HEPATOLOGY 2026.
Maladaptive emergency granulopoiesis predicts poor outcomes in patients hospitalized with decompensated cirrhosis

Aguilar, Ferran; Lozano, Juan Jose; Claria, Joan; Groba, Sara Noemi Reinartz; Richter, Mathis;

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Heyn, Holger; Nieto, Juan C; Soehnlein, Oliver; Rautou, Pierre-Emmanuel; Moreau, Richard.

Referencia:
JOURNAL OF HEPATOLOGY 2026.
Mitochondrial dysfunction governs immunometabolism in leukocytes of patients with acute-on-chronic liver failure

Zhang, Ingrid W; Curto, Anna; Lopez-Vicario, Cristina; Casulleras, Mireia; Duran-Guell, Marta;

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Hernandez-Tejero, Maria; Toapanta, David; Fernandez, Javier; Arroyo, Vicente; Claria, Joan.

Referencia:
JOURNAL OF HEPATOLOGY 2022.
Untargeted lipidomics uncovers lipid signatures distinguishing severe versus moderate forms of acutely decompensated cirrhosis

Claria, Joan; Curto, Anna; Moreau, Richard; Colsch, Benoit; Lopez-Vicario, Cristina;

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Trebicka, Jonel; Fernandez, Javier; Angeli, Paolo; Jalan, Rajiv; Arroyo, Vicente.

Referencia:
JOURNAL OF HEPATOLOGY 2021.
Stimulation of soluble guanylate cyclase exerts antiinflammatory actions in the liver through a VASP/NF-κB/NLRP3 inflammasome circuit

Flores-Costa, Roger; Duran-Guell, Marta; Casulleras, Mireia; Lopez-Vicario, Cristina; Alcaraz-Quiles, Jose;

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Titos, Esther; Hall, Katherine; Sarno, Renee; Masferrer, Jaime L; Claria, Joan.

Referencia:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2020.
Albumin internalizes and inhibits endosomal TLR signaling in leukocytes from patients with decompensated cirrhosis

Casulleras, Mireia; Flores-Costa, Roger; Duran-Guell, Marta; Alcaraz-Quiles, Jose; Sanz, Silvia;

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Costa, Montserrat; de la Grange, Pierre; Moreau, Richard; Arroyo, Vicente; Claria, Joan.

Referencia:
Science Translational Medicine 2020.
Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF

Moreau, Richard; Claria, Joan; Aguilar, Ferran; Fenaille, Francois; Lozano, Juan Jose;

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Gerbes, Alexander; Jalan, Rajiv; Bernardi, Mauro; Arroyo, Vicente; Angeli, Paolo.

Referencia:
JOURNAL OF HEPATOLOGY 2020.
Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: Role for omega-3 epoxides

Lopez-Vicario, Cristina; Alcaraz-Quiles, Jose; Garcia-Alonso, Veronica; Rius, Bibiana; Hwang, Sung H;

Titos, Esther; Lopategi, Aritz; Hammock, Bruce D; Arroyo, Vicente; Claria, Joan.

Referencia:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2015.
Resolvins, Specialized Proresolving Lipid Mediators, and Their Potential Roles in Metabolic Diseases

Spite, Matthew; Claria, Joan; Serhan, Charles N;

Referencia:
Cell Metabolism 2014.