A new molecular mechanism regulates invasiveness and metastasis in carcinomas

Loss of E-cadherin is a key initial step in the invasiveness of primary epithelial tumors and their eventual metastasis. The Group of Transcriptional Regulation at IDIBAPS has identified a new molecular mechanism regulating E-cadherin that could be involved in the initial steps of tumor invasion into surrounding normal tissue and their eventual metastasis.

The work shows that ZEB1, which expression correlates with higher invasiveness in most carcinomas, binds to chromatin remodeling protein BRG1 to repress E-cadherin and induce the expression of mesenchymal markers in colon and breast tumors. The study, funded by the Spanish Ministry of Science and Education, European Union, La Caixa Foundation and Olga Torres Foundation, has been published in Oncogene.