Dr. Ángel Carracedo offers a IDIBAPS Seminar about new genomic strategies against colorectal cancer

Colorectal cancer is related with heritability in around 30% of cases, but only 5% of genetic variance can be attributed to highly penetrant mutations. Thus, the investigators fighting the disease face a very complex problem which can only be solved using the latest genetics and bioinformatics technologies. Dr. Ángel Carracedo, Director of the Centro Nacional de Genotipado (CenGen-ISCIII) at Universidad Santiago de Compostela, is one of these investigators exploring all the opportunities to disclose the key pathways of colorectal cancer. He shared his experience in a IDIBAPS Seminar hosted by Dr. Antoni Castells, which was held in October 14th and entitled: New genomic strategies for the identification of genes involved in colorectal cancer.

Dr. Carracedo explained some of the national and international collaborations that allow a better understanding of colorectal cancer. EPICOLON consortium, for instance, is a highly productive Spanish epidemiologic, prospective, multicentre and population-based study. Another international effort is the COGENT Consortium for Colorectal Cancer Susceptibility, where Genome-Wide Association Studies (GWAS) have allowed the detection of different loci and Single Nucleotide Polymorphisms (SNPs) associated with colorectal cancer. The Human Variome Project, the global initiative to collect and curate all human genetic variation affecting human health, is another of the examples cited by Dr. Carracedo to explain the need of a multidisciplinary approach to research in such a complex disease.

In addition to Genomics, Epigenetics or Pharmacogenomics, which are offering interesting results, Dr. Carracedo explained the rising interest in admixture mapping. Admixture results in the introduction of new genetic lineages into a population, and offers unique information about the importance of genetic variations in the apparition of a genetic disease. His presentation raised a high interest and illustrated the vast experience of the speaker and the benefits of his collaboration with teams like the one directed by Dr. Antoni Castells at IDIBAPS.

Learn about the next IDIBAPS Seminars 2013.