In this study a set of indicators were measured after a meal challenge with either a GLP-1r antagonist or saline infusion in subjects with sustained remission of type 2 diabetes after RYGBP and healthy controls. The presence of the GLP-1r antagonist, which should have altered the glucose metabolism in case GLP-1 action was directly related with type 2 diabetes remission, resulted in marginal deterioration of the 2-h plasma glucose after meal intake in RYGBP subjects. Furthermore, glucose response to meal intake was similarly enlarged in the two study groups. The limited deterioration of glucose tolerance on blockade of GLP-1 action suggests the beneficial effects of RYGBP over type 2 diabetes may not be significantly related with GLP-1 as previously thought.
Reference: Jiménez A, Casamitjana R, Viaplana-Masclans J, Lacy A, Vidal J. GLP-1 Action and Glucose Tolerance in Subjects With Remission of Type 2 Diabetes Mellitus After Gastric Bypass Surgery. Diabetes Care. 2013 Jan 28. [Epub ahead of print]. doi: 10.2337/dc12-1535