After the study of brain tissue from two patients with symptoms such as sleep disorders REM and non-REM behavior, movement and breathing disorders (obstructive apnea), the researchers identified the presence of an antibody against a neuronal protein, IgLON5, responsible for the neurodegenerative process linked to the autoimmune process.
The results allow to diagnose disease was not known so far, and suggest the possibility of a future control inflammatory processes that control turn neurodegeneration in these patients.
Lidia Sabater, Carles Gaig, Ellen Gelpi, Luis Bataller, Jan Lewerenz, Estefanía Torres-Vega, Angeles Contreras, Bruno Giometto, Yaroslau Compta, Cristina Embid, Isabel Vilaseca, Alex Iranzo, Joan Santamaría, Josep Dalmau, Francesc Graus. A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study. The Lancet Neurology, Early Online Publication,3 April 2014. doi:10.1016/S1474-4422(14)70051-1