Martín-Subero received a “Synergy Grant” from the ERC in 2019, along with Elías Campo and the CNAG researchers Holger Heyn and Ivo Gut, to explore the potential of new sequencing technologies—including single-cell sequencing—with the aim of better understanding the origin, evolution and clinical behaviour of this haematological disease. (Click here to see the news item)
The ERC “Proof of Concept” programme is designed to support principal investigators who have already received ERC funding, and aims to facilitate the validation of ideas generated during the funded projects. The grant offers up to €150,000 for a period of 18 months.
The new project led by Martín-Subero’s group aims to develop a personalized prognostic model based on various layers of epigenetic memory estimated via DNA methylation. It is based on three previous studies that demonstrated that the cell of origin, proliferative history and evolutionary dynamics (the latter developed in the context of the ERC Synergy project) allow the prognosis of patients to be estimated independently.
With this new initiative, the group aims to integrate the three layers of epigenetic memory in an innovative tool capable of estimating prognosis with great precision, and developing a product applicable to clinical practice, which can be implemented in hospital settings.
Last year, another IDIBAPS researcher, Marc Claret, also received an ERC "Proof of Concept Grant” to study the regulation of mitochondrial metabolism as a potential therapeutic target for treating obesity and ageing. (Click here to see the news item)
