Joan-Marc Servitja

About me

Featured publications

• Cryo-EM exposes diverse polymorphism in IAPP mutants to guide the rational design of peptide-based therapeutics

  Authors:

  Ooi, Saik Ann; Valli, Dylan; Kuska, Mikolaj I; Mari, Helena; Chaudhary, Himanshu;

  (...)

  Westenhoff, Sebastian; Tietze, Alesia A; Novials, Anna; Servitja, Joan-Marc; Maj, Michal.

  See complete list of authors

  Reference: Journal Of Molecular Biology 2025.

• Diet-Induced Obesity Disrupts Sexually Dimorphic Gene Expression in Mice.

  Authors:

  Ribas V; Morón-Ros S; Marí H; Gracia-Batllori A; Brugnara L;

  (...)

  Eyre E; Claret M; Marco-Rius I; Novials A; Servitja JM.

  See complete list of authors

  Reference: American Journal Of Physiology-Cell Physiology 2025.

• People with type 1 diabetes exhibit lower exercise capacity compared to a control population with similar physical activity levels

  Authors:

  Murillo, Serafin; Brugnara, Laura; Rios, Santiago; Ribas, Vicent; Servitja, Joan-Marc;

  Novials, Anna.

  Reference: Diabetes Research And Clinical Practice 2024.

• High Intensity Interval Training reduces hypoglycemic events compared with continuous aerobic training in individuals with type 1 diabetes: HIIT and hypoglycemia in type 1 diabetes

  Authors:

  Murillo, Serafin; Brugnara, Laura; Servitja, Joan-Marc; Novials, Anna;

  Reference: Diabetes & Metabolism 2022.

• BACE2 suppression in mice aggravates the adverse metabolic consequences of an obesogenic diet

  Authors:

  Diaz-Catalan, Daniela; Alcarraz-Vizan, Gema; Castano, Carlos; de Pablo, Sara; Rodriguez-Comas, Julia;

  (...)

  Ramirez, Sara; Claret, Marc; Parrizas, Marcelina; Novials, Anna; Servitja, Joan -Marc.

  See complete list of authors

  Reference: Molecular Metabolism 2021.

• 4-Phenylbutyrate (PBA) treatment reduces hyperglycemia and islet amyloid in a mouse model of type 2 diabetes and obesity

  Authors:

  de Pablo, Sara; Rodriguez-Comas, Julia; Diaz-Catalan, Daniela; Alcarraz-Vizan, Gema; Castano, Carlos;

  Moreno-Vedia, Juan; Montane, Joel; Parrizas, Marcelina; Servitja, Joan-Marc; Novials, Anna.

  Reference: Scientific Reports 2021.

• Alpha1-antitrypsin ameliorates islet amyloid-induced glucose intolerance and β-cell dysfunction

  Authors:

  Rodriguez-Comas, Julia; Moreno-Vedia, Juan; Obach, Merce; Castano, Carlos; de Pablo, Sara;

  (...)

  Mestre, Anna; Horrillo, Raquel; Costa, Montserrat; Novials, Anna; Servitja, Joan-Marc.

  See complete list of authors

  Reference: Molecular Metabolism 2020.

• Stress-Induced MicroRNA-708 Impairs β-Cell Function and Growth.

  Authors:

  Rodriguez-Comas, Julia; Moreno-Asso, Alba; Moreno-Vedia, Juan; Martin, Merce; Castano, Carlos;

  (...)

  Montane, Joel; Fillat, Cristina; Gasa, Rosa; Novials, Anna; Servitja, Joan-Marc.

  See complete list of authors

  Reference: Diabetes 2017.

• Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control.

  Authors:

  Ramirez, Sara; Gomez-Valades, Alicia G; Schneeberger, Marc; Varela, Luis; Haddad-Tovolli, Roberta;

  (...)

  Servitja, Joan-Marc; Horvath, Tamas L; Gomis, Ramon; Zorzano, Antonio; Claret, Marc.

  See complete list of authors

  Reference: Cell Metabolism 2017.

• Circulating miR-192 and miR-193b are markers of prediabetes and are modulated by an exercise intervention

  Authors:

  Parrizas, Marcelina; Brugnara, Laura; Esteban, Yaiza; Gonzalez-Franquesa, Alba; Canivell, Silvia;

  (...)

  Cusso, Roser; Cadefau, Joan A; Garcia-Roves, Pablo M; Servitja, Joan-Marc; Novials, Anna.

  See complete list of authors

  Reference: Journal Of Clinical Endocrinology & Metabolism 2015.

Featured Projects

• Inter-organ cross-talk and type 2 diabetes: effects of circulating exosomes on pancreatic islets

  Principal investigator: Anna Maria Novials Sarda, Joan Marc Servitja Duque

  Funder: Instituto de Salud Carlos III

  Code: PI20/00658

  Duration: 01/01/2021 - 31/12/2023

• Benchtop NMR for Lab-On-Chip (BLOC)

  Principal investigator: Joan Marc Servitja Duque

  Funder: European Commission

  Code: 863037

  Duration: 01/01/2020 - 31/12/2023

  Web: https://blocproject.eu/

• BACE2, una nueva diana terapéutica para el tratamiento de la diabetes tipo 2 y la obesidad.

  Principal investigator: Joan Marc Servitja Duque, Anna Maria Novials Sarda

  Funder: Instituto de Salud Carlos III

  Code: PI17/00879

  Duration: 01/01/2018 - 31/12/2020

• Effects of physical exercise implementation in type 2 diabetes: extracellular vesicles as biomarkers and response mediators in cardiovascular protection

  Principal investigator: Joan Marc Servitja Duque, Joan-Marc Servitja

  Funder: Instituto de Salud Carlos III

  Code: PI23/00514

  Duration: 01/01/2024 - 31/12/2026

• Effects of circulating extracellular vesicles on pancreatic islets during obesity

  Principal investigator: Joan Marc Servitja Duque

  Funder: European Federation for the Study of Diebetes

  Code: EFSD/BI/2023

  Duration: 09/01/2023 - 31/01/2026