
Joan-Marc Servitja
Research group
- Pathogenesis and prevention of diabetes Accredited researcher (R3A)
About me
Dr. Joan-Marc Servitja is a senior researcher at the group Pathogenesis and Prevention of Diabetes, leading different projects related to islet biology and diabetes. He has also received contracts from the pharmaceutical industry in order to test novel applications of existing drugs as potential treatments for type 1 and type 2 diabetes. During the last years, he has authored more than 20 articles on diabetes research published in high impact journals.
Currently, he is leading different research lines focused on the regulation of gene expression and inter-organ cross-talk in pancreatic islets with the ultimate goal to design novel therapeutic strategies for the treatment of type 2 diabetes.
Featured publications
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Cryo-EM exposes diverse polymorphism in IAPP mutants to guide the rational design of peptide-based therapeutics
Authors:Reference: Journal Of Molecular Biology 2025. -
Diet-Induced Obesity Disrupts Sexually Dimorphic Gene Expression in Mice.
Authors:Reference: American Journal Of Physiology-Cell Physiology 2025. -
People with type 1 diabetes exhibit lower exercise capacity compared to a control population with similar physical activity levels
Authors:Reference: Diabetes Research And Clinical Practice 2024. -
High Intensity Interval Training reduces hypoglycemic events compared with continuous aerobic training in individuals with type 1 diabetes: HIIT and hypoglycemia in type 1 diabetes
Authors:Reference: Diabetes & Metabolism 2022. -
BACE2 suppression in mice aggravates the adverse metabolic consequences of an obesogenic diet
Authors:Reference: Molecular Metabolism 2021. -
4-Phenylbutyrate (PBA) treatment reduces hyperglycemia and islet amyloid in a mouse model of type 2 diabetes and obesity
Authors:Reference: Scientific Reports 2021. -
Alpha1-antitrypsin ameliorates islet amyloid-induced glucose intolerance and β-cell dysfunction
Authors:Reference: Molecular Metabolism 2020. -
Stress-Induced MicroRNA-708 Impairs β-Cell Function and Growth.
Authors:Reference: Diabetes 2017. -
Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control.
Authors:Reference: Cell Metabolism 2017. -
Circulating miR-192 and miR-193b are markers of prediabetes and are modulated by an exercise intervention
Authors:Reference: Journal Of Clinical Endocrinology & Metabolism 2015.
Featured Projects
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Inter-organ cross-talk and type 2 diabetes: effects of circulating exosomes on pancreatic islets
Principal investigator: Anna Maria Novials Sarda, Joan Marc Servitja DuqueFunder: Instituto de Salud Carlos IIICode: PI20/00658Duration: 01/01/2021 - 31/12/2023 -
Benchtop NMR for Lab-On-Chip (BLOC)
Principal investigator: Joan Marc Servitja DuqueFunder: European CommissionCode: 863037Duration: 01/01/2020 - 31/12/2023 -
BACE2, una nueva diana terapéutica para el tratamiento de la diabetes tipo 2 y la obesidad.
Principal investigator: Joan Marc Servitja Duque, Anna Maria Novials SardaFunder: Instituto de Salud Carlos IIICode: PI17/00879Duration: 01/01/2018 - 31/12/2020 -
Effects of physical exercise implementation in type 2 diabetes: extracellular vesicles as biomarkers and response mediators in cardiovascular protection
Principal investigator: Joan Marc Servitja Duque, Joan-Marc ServitjaFunder: Instituto de Salud Carlos IIICode: PI23/00514Duration: 01/01/2024 - 31/12/2026 -
Effects of circulating extracellular vesicles on pancreatic islets during obesity
Principal investigator: Joan Marc Servitja DuqueFunder: European Federation for the Study of DiebetesCode: EFSD/BI/2023Duration: 09/01/2023 - 31/01/2026