Joan-Marc Servitja

About me

Featured publications

• BACE2 suppression in mice aggravates the adverse metabolic consequences of an obesogenic diet

  Authors: Díaz-Catalán D, Alcarraz-Vizán G, Castaño C, de Pablo S, Rodríguez-Comas J, Fernández-Pérez A, Vallejo M, Ramírez S, Claret M, Parrizas M, Novials A, Servitja JM .

  Reference: Molecular Metabolism 2021.

• 4-Phenylbutyrate (PBA) treatment reduces hyperglycemia and islet amyloid in a mouse model of type 2 diabetes and obesity

  Authors: de Pablo S, Rodríguez-Comas J, Díaz-Catalán D, Alcarraz-Vizán G, Castaño C, Moreno-Vedia J, Montane J, Parrizas M, Servitja JM, Novials A .

  Reference: Scientific Reports 2021.

• Alpha1-antitrypsin ameliorates islet amyloid-induced glucose intolerance and β-cell dysfunction

  Authors: Rodríguez-Comas J, Moreno-Vedia J, Obach M, Castaño C, de Pablo S, Alcarraz-Vizán G, Díaz-Catalán D, Mestre A, Horrillo R, Costa M, Novials A, Servitja JM .

  Reference: Molecular Metabolism 2020.

• Stress-Induced MicroRNA-708 Impairs β-Cell Function and Growth.

  Authors: Rodríguez-Comas J, Moreno-Asso A, Moreno-Vedia J, Martín M, Castaño C, Marzà-Florensa A, Bofill-De Ros X, Mir-Coll J, Montané J, Fillat C, Gasa R, Novials A, Servitja JM .

  Reference: Diabetes 2017.

• Amyloid-induced beta-cell dysfunction and islet inflammation are ameliorated by 4-phenylbutyrate (PBA) treatment

  Authors: Montane, Joel; de Pablo, Sara; Castano, Carlos; Rodriguez-Comas, Julia; Cadavez, Lisa; Obach, Merce; Visa, Montse; Alcarraz-Vizan, Gema; Sanchez-Martinez, Melchor; Nonell-Canals, Alfons; Parrizas, Marcelina; Servitja, Joan-Marc; Novials, Anna;.

  Reference: Faseb Journal 2017.

• Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control.

  Authors: Ramírez S, Gómez-Valadés AG, Schneeberger M, Varela L, Haddad-Tóvolli R, Altirriba J, Noguera E, Drougard A, Flores-Martínez Á, Imbernón M, Chivite I, Pozo M, Vidal-Itriago A, Garcia A, Cervantes S, Gasa R, Nogueiras R, Gama-Pérez P, Garcia-Roves PM, Cano DA, Knauf C, Servitja JM, Horvath TL, Gomis R, Zorzano A, Claret M .

  Reference: Cell Metabolism 2017.

• BACE2 suppression promotes β-cell survival and function in a model of type 2 diabetes induced by human islet amyloid polypeptide overexpression.

  Authors: Alcarraz-Vizán G, Castaño C, Visa M, Montane J, Servitja JM, Novials A .

  Reference: Cellular And Molecular Life Sciences 2017.

• Islet amyloid polypeptide exerts a novel autocrine action in b-cell signaling and proliferation

  Authors: Visa M., Alcarraz-Vi?an G., Montane J., Cadavez L., Castaño C., Villanueva-Peñacarrillo M., Servitja J., Novials A..

  Reference: Faseb Journal 2015.

• Circulating miR-192 and miR-193b are markers of prediabetes and are modulated by an exercise intervention

  Authors: Párrizas M., Brugnara L., Esteban Y., González-Franquesa A., Canivell S., Murillo S., Gordillo-Bastidas E., Cussó R., Cadefau J., García-Roves P., Servitja J., Novials A..

  Reference: Journal Of Clinical Endocrinology & Metabolism 2015.

• Glucose regulation of a cell cycle gene module is selectively lost in mouse pancreatic islets during ageing

  Authors: Moreno-Asso, A; Castano, C; Grilli, A; Novials, A; Servitja, J-M.

  Reference: Diabetologia 2013.

Featured Projects

• Inter-organ cross-talk and type 2 diabetes: effects of circulating exosomes on pancreatic islets

  Principal investigator: Anna Maria Novials Sarda, Joan Marc Servitja Duque

  Funder: ISCIII Ministerio de Ciencia e Innovacion)

  Code: PI20/00658

  Duration: 01/01/2021 - 31/12/2023

• Benchtop NMR for Lab-On-Chip (BLOC)

  Principal investigator: Joan Marc Servitja Duque

  Funder: European Union – H2020 (Programa financiador competitivo)

  Code: 863037

  Duration: 01/01/2020 - 31/12/2022

  Web: https://blocproject.eu/

• BACE2, una nueva diana terapéutica para el tratamiento de la diabetes tipo 2 y la obesidad.

  Principal investigator: Joan Marc Servitja Duque, Anna Maria Novials Sarda

  Funder: ISCIII Ministerio de Ciencia e Innovacion) (Programa financiador competitivo)

  Code: PI17/00879

  Duration: 01/01/2018 - 31/12/2020

• Nuevas estrategias para el tratamiento de la diabetes: intervención sobre el estrés de retículo endoplásmico y la inflamación inducidos por los depósitos de amiloide en el islote pancreático.

  Principal investigator: Joan Marc Servitja Duque, Anna Maria Novials Sarda

  Funder: CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER (Sede); Instituto de Salud Carlos III

  Code: PI14/00447

  Duration: 01/01/2015 - 31/12/2017

• Potential protective effects of an anti-inflammatory molecule on pancreatic beta-cells.

  Principal investigator: Joan Marc Servitja Duque, Anna Maria Novials Sarda

  Funder: CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER (Sede); Instituto Grifols, S.A. ; Instituto Grifols, S.A. (Participante)

  Duration: 01/01/2013