Joan-Marc Servitja
Grup de recerca
- Patogènia i prevenció de la diabetis Accredited researcher (R3A)
Sobre mi
Dr. Joan-Marc Servitja is a senior researcher at the group Pathogenesis and Prevention of Diabetes, leading different projects related to islet biology and diabetes. He has also received contracts from the pharmaceutical industry in order to test novel applications of existing drugs as potential treatments for type 1 and type 2 diabetes. During the last years, he has authored more than 20 articles on diabetes research published in high impact journals.
Currently, he is leading different research lines focused on the regulation of gene expression and inter-organ cross-talk in pancreatic islets with the ultimate goal to design novel therapeutic strategies for the treatment of type 2 diabetes.
Publicacions destacades
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4-Phenylbutyrate (PBA) treatment reduces hyperglycemia and islet amyloid in a mouse model of type 2 diabetes and obesity
Autors: de Pablo S, Rodríguez-Comas J, Díaz-Catalán D, Alcarraz-Vizán G, Castaño C, Moreno-Vedia J, Montane J, Parrizas M, Servitja JM, Novials A .Referència: Sci Rep 2021. -
BACE2 suppression in mice aggravates the adverse metabolic consequences of an obesogenic diet
Autors: Díaz-Catalán D, Alcarraz-Vizán G, Castaño C, de Pablo S, Rodríguez-Comas J, Fernández-Pérez A, Vallejo M, Ramírez S, Claret M, Parrizas M, Novials A, Servitja JM .Referència: Molecular Metabolism 2021. -
Alpha1-antitrypsin ameliorates islet amyloid-induced glucose intolerance and β-cell dysfunction
Autors: Rodríguez-Comas J, Moreno-Vedia J, Obach M, Castaño C, de Pablo S, Alcarraz-Vizán G, Díaz-Catalán D, Mestre A, Horrillo R, Costa M, Novials A, Servitja JM .Referència: Molecular Metabolism 2020. -
Stress-Induced MicroRNA-708 Impairs β-Cell Function and Growth.
Autors: Rodríguez-Comas J, Moreno-Asso A, Moreno-Vedia J, Martín M, Castaño C, Marzà-Florensa A, Bofill-De Ros X, Mir-Coll J, Montané J, Fillat C, Gasa R, Novials A, Servitja JM .Referència: Diabetes 2017. -
BACE2 suppression promotes β-cell survival and function in a model of type 2 diabetes induced by human islet amyloid polypeptide overexpression.
Autors: Alcarraz-Vizán G, Castaño C, Visa M, Montane J, Servitja JM, Novials A .Referència: Cellular And Molecular Life Sciences 2017. -
Mitochondrial Dynamics Mediated by Mitofusin 1 Is Required for POMC Neuron Glucose-Sensing and Insulin Release Control.
Autors: Ramírez S, Gómez-Valadés AG, Schneeberger M, Varela L, Haddad-Tóvolli R, Altirriba J, Noguera E, Drougard A, Flores-Martínez Á, Imbernón M, Chivite I, Pozo M, Vidal-Itriago A, Garcia A, Cervantes S, Gasa R, Nogueiras R, Gama-Pérez P, Garcia-Roves PM, Cano DA, Knauf C, Servitja JM, Horvath TL, Gomis R, Zorzano A, Claret M .Referència: Cell Metabolism 2017. -
Amyloid-induced beta-cell dysfunction and islet inflammation are ameliorated by 4-phenylbutyrate (PBA) treatment
Autors: Montane, Joel; de Pablo, Sara; Castano, Carlos; Rodriguez-Comas, Julia; Cadavez, Lisa; Obach, Merce; Visa, Montse; Alcarraz-Vizan, Gema; Sanchez-Martinez, Melchor; Nonell-Canals, Alfons; Parrizas, Marcelina; Servitja, Joan-Marc; Novials, Anna;.Referència: Faseb Journal 2017. -
Islet amyloid polypeptide exerts a novel autocrine action in b-cell signaling and proliferation
Autors: Visa M., Alcarraz-Vi?an G., Montane J., Cadavez L., Castaño C., Villanueva-Peñacarrillo M., Servitja J., Novials A..Referència: Faseb Journal 2015. -
Circulating miR-192 and miR-193b are markers of prediabetes and are modulated by an exercise intervention
Autors: Párrizas M., Brugnara L., Esteban Y., González-Franquesa A., Canivell S., Murillo S., Gordillo-Bastidas E., Cussó R., Cadefau J., García-Roves P., Servitja J., Novials A..Referència: Journal Of Clinical Endocrinology & Metabolism 2015. -
Glucose regulation of a cell cycle gene module is selectively lost in mouse pancreatic islets during ageing
Autors: Moreno-Asso, A; Castano, C; Grilli, A; Novials, A; Servitja, J-M.Referència: Diabetologia 2013.
Projectes destacats
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Inter-organ cross-talk and type 2 diabetes: effects of circulating exosomes on pancreatic islets
Investigador/a principal: Joan Marc Servitja Duque, Anna Maria Novials SardaFinançador: ISCIII Ministerio de Ciencia e Innovacion)Codi: PI20/00658Durada: 01/01/2021 - 31/12/2023 -
Benchtop NMR for Lab-On-Chip (BLOC)
Investigador/a principal: Joan Marc Servitja DuqueFinançador: European Union – H2020 (Programa financiador competitivo)Codi: 863037Durada: 01/01/2020 - 31/12/2022 -
BACE2, una nueva diana terapéutica para el tratamiento de la diabetes tipo 2 y la obesidad.
Investigador/a principal: Joan Marc Servitja Duque, Anna Maria Novials SardaFinançador: ISCIII Ministerio de Ciencia e Innovacion) (Programa financiador competitivo)Codi: PI17/00879Durada: 01/01/2018 - 31/12/2020 -
Nuevas estrategias para el tratamiento de la diabetes: intervención sobre el estrés de retículo endoplásmico y la inflamación inducidos por los depósitos de amiloide en el islote pancreático.
Investigador/a principal: Joan Marc Servitja Duque, Anna Maria Novials SardaFinançador: CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER (Sede); Instituto de Salud Carlos IIICodi: PI14/00447Durada: 01/01/2015 - 31/12/2017 -
Potential protective effects of an anti-inflammatory molecule on pancreatic beta-cells.
Investigador/a principal: Joan Marc Servitja Duque, Anna Maria Novials SardaFinançador: CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER (Sede); Instituto Grifols, S.A. ; Instituto Grifols, S.A. (Participante)Durada: 01/01/2013