Josep Dalmau

About me

Featured publications

• Clinical characterisation of patients in the post-acute stage of anti-NMDA receptor encephalitis: a prospective cohort study and comparison with patients with schizophrenia spectrum disorders

  Authors: Guasp M, Rosa-Justicia M, Muñoz-Lopetegi A, Martínez-Hernández E, Armangué T, Sugranyes G, Stein H, Borràs R, Prades L, Ariño H, Planagumà J, De-La-Serna E, Escudero D, Llufriu S, Sánchez-Valle R, Santamaria J, Compte A, Castro-Fornieles J, Dalmau J, Spanish anti-NMDAR Encephalitis Study Group.

  Reference: Lancet Neurology 2022.

• Human CASPR2 Antibodies Reversibly Alter Memory and the CASPR2 Protein Complex

  Authors: Joubert B, Petit-Pedrol M, Planagumà J, Mannara F, Radosevic M, Marsal M, Maudes E, García-Serra A, Aguilar E, Andrés-Bilbé A, Gasull X, Loza-Alvarez P, Sabater L, Rosenfeld MR, Dalmau J .

  Reference: Annals Of Neurology 2022.

• Neurofilament Light Chain Levels in Anti-NMDAR Encephalitis and Primary Psychiatric Psychosis

  Authors: Guasp M, Martín-Aguilar L, Sabater L, Bioque M, Armangué T, Martínez-Hernández E, Landa J, Maudes E, Borràs R, Muñoz-Lopetegi A, Saiz A, Castro-Fornieles J, Graus F, Parellada E, Querol L, Dalmau J .

  Reference: Neurology 2022.

• Clinical, Neuroimmunologic, and CSF Investigations in First Episode Psychosis

  Authors: Guasp M, Giné-Servén E, Maudes E, Rosa-Justicia M, Martínez-Hernández E, Boix-Quintana E, Bioque M, Casado V, Módena-Ouarzi Y, Guanyabens N, Muriana D, Sugranyes G, Pacchiarotti I, Davi-Loscos E, Torres-Rivas C, Ríos J, Sabater L, Saiz A, Graus F, Castro-Fornieles J, Parellada E, Dalmau J .

  Reference: Neurology 2021.

• Allosteric modulation of NMDA receptors prevents the antibody effects of patients with anti-NMDAR encephalitis

  Authors: Mannara F, Radosevic M, Planagumà J, Soto D, Aguilar E, García-Serra A, Maudes E, Pedreño M, Paul S, Doherty J, Quirk M, Dai J, Gasull X, Lewis M, Dalmau J .

  Reference: Brain 2020.

• LGI1 antibodies alter Kv1.1 and AMPA receptors changing synaptic excitability, plasticity and memory

  Authors: Petit-Pedrol M; Sell J; Planagumà J; Mannara F; Radosevic M; Haselmann H; Ceanga M; Sabater L; Spatola M; Soto D; Gasull X; Dalmau J; Geis C.

  Reference: Brain 2018.

• Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex encephalitis: a prospective observational study and retrospective analysis

  Authors: Armangue T, Spatola M, Vlagea A, Mattozzi S, Cárceles-Cordon M, Martinez-Heras E, Llufriu S, Muchart J, Erro ME, Abraira L, Moris G, Monros-Giménez L, Corral-Corral Í, Montejo C, Toledo M, Bataller L, Secondi G, Ariño H, Martínez-Hernández E, Juan M, Marcos MA, Alsina L, Saiz A, Rosenfeld MR, Graus F, Dalmau J, Spanish Herpes Simplex Encephalitis Study Group.

  Reference: Lancet Neurology 2018.

• Investigations in GABAA receptor antibody-associated encephalitis.

  Authors: Spatola, Marianna; Petit-Pedrol, Mar; Simabukuro, Mateus Mistieri; Armangue, Thas; Castro, Fernanda J.; Barcelo Artigues, Maria I.; Julia Benique, Maria R.; Benson, Leslie; Gorman, Mark; Felipe, Ana; Oblitas, Ruben L. Caparo; Rosenfeld, Myrna R.; Graus, Francesc; Dalmau, Josep;.

  Reference: Neurology 2017.

• Human N-methyl D-aspartate receptor antibodies alter memory and behaviour in mice

  Authors: Planaguma, Jesus; Leypoldt, Frank; Mannara, Francesco; Gutierrez-Cuesta, Javier; Martin-Garcia, Elena; Aguilar, Esther; Titulaer, Maarten J.; Petit-Pedrol, Mar; Jain, Ankit; Balice-Gordon, Rita; Lakadamyali, Melike; Graus, Francesc; Maldonado, Rafael; Dalmau, Josep;.

  Reference: Brain 2015.

• Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study

  Authors: Titulaer, Maarten J; Mccracken, Lindsey; Gabilondo, Inigo; Armangue, Thais; Glaser, Carol; Iizuka, Takahiro; Honig, Lawrence S; Benseler, Susanne M; Kawachi, Izumi; Martinez-Hernandez, Eugenia; Aguilar, Esther; Gresa-Arribas, Nuria; Ryan-Florance, Nicole; Torrents, Abiguei; Saiz, Albert; Rosenfeld, Myrna R; Balice-Gordon, Rita; Graus, Francesc; Dalmau, Josep.

  Reference: Lancet Neurology 2013.

Featured Projects

• Antibody-mediated NMDA receptor encephalitis: symptoms, biomarkers, and mechanisms of the prolonged recovery stage

  Principal investigator: Josep Dalmau Obrador

  Funder: Fundación La Caixa

  Code: HR22-00221

  Duration: 01/12/2022 - 30/11/2025

• Investigations in anti-NMDAR encephalitis: New diagnostic test, the role of inflammation in an animal model, and allosteric modulation of NMDAR as a therapeutic strategy

  Principal investigator: Josep Dalmau Obrador

  Funder: Instituto de Salud Carlos III

  Code: PI20/00197

  Duration: 01/01/2021 - 31/12/2023

• A Phase-2b, Double-Blind, Randomized Controlled Trial to Evaluate the Activity and Safety of Inebilizumab in Anti-NMDA Receptor Encephalitis and Assess Markers of Disease

  Principal investigator: Josep Dalmau Obrador

  Funder: NeuroNext National Institutes of Health USA

  Duration: 18/01/2023 - 31/03/2027

• Social and Psychological long-term impact of NMDA receptor encephalitis

  Principal investigator: Josep Dalmau Obrador

  Funder: Instituto de Salud Carlos III

  Code: AC21-2/00053

  Duration: 01/01/2022 - 31/12/2024