Manuel Morales-Ruiz

Research group

Biomarkers and laboratory precision medicine in hepatology, metabolism, and rare diseases (HEMERA-Lab) Group leader (R4)

morales@clinic.cat 0000-0002-9074-2272

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Featured publications

miR-122 Deficiency in Mice Enhances Regeneration in Healthy Liver but Drives Pathological Repair and Functional Decline in Fibrotic Liver

Authors:
Ribera, Jordi; Cardona-Simó, Anna; Portolés, Irene; Samper, Esther; Boix, Loreto;

(...)

Desdouets, Chantal; Melgar-Lesmes, Pedro; Jiménez, Wladimiro; Casals, Gregori; Morales-Ruiz, Manuel.

Reference: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2026.
Identification of Dhx15 as a Major Regulator of Liver Development, Regeneration, and Tumor Growth in Zebrafish and Mice.

Authors:
Portoles, Irene; Ribera, Jordi; Fernandez-Galan, Esther; Lecue, Elena; Casals, Gregori;

(...)

Sanduzzi, Marco; Aishwarya, Veenu; Reig, Maria; Jimenez, Wladimiro; Morales-Ruiz, Manuel.

Reference: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2024.
Tcf20 deficiency is associated with increased liver fibrogenesis and alterations in mitochondrial metabolism in mice and humans

Authors:
Cordoba-Jover, Bernat; Ribera, Jordi; Portoles, Irene; Lecue, Elena; Rodriguez-Vita, Juan;

(...)

Pinyol, Roser; Huguet-Pradell, Julia; Melgar-Lesmes, Pedro; Jimenez, Wladimiro; Morales-Ruiz, Manuel.

Reference: LIVER INTERNATIONAL 2023.
The loss of DHX15 impairs endothelial energy metabolism, lymphatic drainage and tumor metastasis in mice

Authors:
Ribera, Jordi; Portoles, Irene; Cordoba-Jover, Bernat; Rodriguez-Vita, Juan; Casals, Gregori;

(...)

Espadas, Guadalupe; Sabido, Eduard; Jimenez, Wladimiro; Sessa, William C; Morales-Ruiz, Manuel.

Reference: Commun Biol 2021.
Treatment of Hepatic Fibrosis in Mice Based on Targeted Plasmonic Hyperthermia

Authors:
Ribera, J; Vilches, C; Sanz, V; de Miguel, I; Portolés, I;

(...)

Prat, E; Nunes, V; Jiménez, W; Quidant, R; Morales-Ruiz, M.

Reference: ACS Nano 2021.
A SMALL POPULATION OF LIVER ENDOTHELIAL CELLS UNDERGOES ENDOTHELIAL TO MESENCHYMAL TRANSITION IN RESPONSE TO CHRONIC LIVER INJURY.

Authors:
Ribera, Jordi; Pauta, Montse; Melgar-Lesmes, Pedro; Cordoba, Bernat; Bosch, Anna;

(...)

Rodrigo-Torres, Daniel; Sancho-Bru, Pau; Mira, Aurea; Jimenez, Wladimiro; Morales-Ruiz, Manuel.

Reference: AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 2017.
Akt-mediated foxo1 inhibition is required for liver regeneration

Authors:
Pauta, M; Rotllan, N; Fernandez-Hernando, A; Langhi, C; Ribera, J;

(...)

Ford, DA; Baldan, A; Birnbaum, MJ; Morales-Ruiz, M; Fernandez-Hernando, C.

Reference: HEPATOLOGY 2016.
Overexpression of angiopoietin-2 in rats and patients with liver fibrosis. Therapeutic consequences of its inhibition

Authors:
Pauta, Montse; Ribera, Jordi; Melgar-Lesmes, Pedro; Casals, Gregori; Rodriguez-Vita, Juan;

(...)

Bataller, Ramon; Michelena, Javier; Altamirano, Jose; Jimenez, Wladimiro; Morales-Ruiz, Manuel.

Reference: LIVER INTERNATIONAL 2015.
Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates

Authors:
Lee, Monica Y; Luciano, Amelia K; Ackah, Eric; Rodriguez-Vita, Juan; Bancroft, Tara A;

Eichmann, Anne; Simons, Michael; Kyriakides, Themis R; Morales-Ruiz, Manuel; Sessa, William C.

Reference: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2014.
Impaired liver regeneration in Ldlr-/- mice is associated with an altered hepatic profile of cytokines, growth factors, and lipids

Authors:
Pauta, Montse; Rotllan, Noemi; Vales, Frances; Fernandez-Hernando, Ana; Allen, Ryan M;

(...)

Mari, Montserrat; Jimenez, Wladimiro; Baldan, Angel; Morales-Ruiz, Manuel; Fernandez-Hernando, Carlos.

Reference: JOURNAL OF HEPATOLOGY 2013.

Featured Projects

Function and therapeutic potential of RNA helicases and miR-122a-5p in liver regeneration and cancer

Principal investigator: Manuel Morales Ruiz

Funder: Agencia Estatal de Investigacion (AEI)

Code: PID2022-138243OB-I00

Duration: 01/10/2024 - 31/03/2026
Grup de recerca traslacional en noves estratègies de diagnòstic i tractament de la malaltia hepàtica

Principal investigator: Manuel Morales Ruiz

Funder: Generalitat de Catalunya

Code: 2021-SGR-00881

Duration: 01/01/2022 - 30/06/2025
Estimulacion de la regeneracion funcional de higados cirroticos mediante la normalizacion vascular intrahepatica y la modulacion de dianas de akt

Principal investigator: Manuel Morales Ruiz

Funder: DGICYT (Dirección General de Investigación Científica y Técnica)

Code: SAF2016-75358-R

Duration: 30/12/2016 - 31/12/2020
Nuevos mecanismos moleculares y nuevas estrategias terapéuticas aplicables a la conservación de la función hepática y a la mejora de la enfermedad hepática crónica

Principal investigator: Manuel Morales Ruiz

Funder: Agencia Estatal de Investigacion (AEI)

Code: PID2019-105502RB-I00

Duration: 01/01/2020 - 30/06/2023
Simvastatin and Rifaximin as new therapy for patients with decompensated cirrhosis (Liver Hope)

Principal investigator: Pere Ginès

Funder: European Comission

Code: CE_H2020- SC1_16abr1s-731875

Duration: 01/01/2017 - 28/02/2023

Manuel Morales-Ruiz

Research group

Featured publications

Featured Projects

Function and therapeutic potential of RNA helicases and miR-122a-5p in liver regeneration and cancer

Grup de recerca traslacional en noves estratègies de diagnòstic i tractament de la malaltia hepàtica

Estimulacion de la regeneracion funcional de higados cirroticos mediante la normalizacion vascular intrahepatica y la modulacion de dianas de akt

Nuevos mecanismos moleculares y nuevas estrategias terapéuticas aplicables a la conservación de la función hepática y a la mejora de la enfermedad hepática crónica

Simvastatin and Rifaximin as new therapy for patients with decompensated cirrhosis (Liver Hope)

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