Manuel Morales-Ruiz

Grup de recerca

Biomarcadors i medicina de precisió de laboratori en hepatologia, metabolisme i malalties rares (HEMERA-Lab) Group leader (R4)

morales@clinic.cat 0000-0002-9074-2272

Segueix-lo/a a:

Publicacions destacades

miR-122 Deficiency in Mice Enhances Regeneration in Healthy Liver but Drives Pathological Repair and Functional Decline in Fibrotic Liver

Autors:
Ribera, Jordi; Cardona-Simó, Anna; Portolés, Irene; Samper, Esther; Boix, Loreto;

(...)

Desdouets, Chantal; Melgar-Lesmes, Pedro; Jiménez, Wladimiro; Casals, Gregori; Morales-Ruiz, Manuel.

Referència: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2026.
Identification of Dhx15 as a Major Regulator of Liver Development, Regeneration, and Tumor Growth in Zebrafish and Mice.

Autors:
Portoles, Irene; Ribera, Jordi; Fernandez-Galan, Esther; Lecue, Elena; Casals, Gregori;

(...)

Sanduzzi, Marco; Aishwarya, Veenu; Reig, Maria; Jimenez, Wladimiro; Morales-Ruiz, Manuel.

Referència: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2024.
Tcf20 deficiency is associated with increased liver fibrogenesis and alterations in mitochondrial metabolism in mice and humans

Autors:
Cordoba-Jover, Bernat; Ribera, Jordi; Portoles, Irene; Lecue, Elena; Rodriguez-Vita, Juan;

(...)

Pinyol, Roser; Huguet-Pradell, Julia; Melgar-Lesmes, Pedro; Jimenez, Wladimiro; Morales-Ruiz, Manuel.

Referència: LIVER INTERNATIONAL 2023.
The loss of DHX15 impairs endothelial energy metabolism, lymphatic drainage and tumor metastasis in mice

Autors:
Ribera, Jordi; Portoles, Irene; Cordoba-Jover, Bernat; Rodriguez-Vita, Juan; Casals, Gregori;

(...)

Espadas, Guadalupe; Sabido, Eduard; Jimenez, Wladimiro; Sessa, William C; Morales-Ruiz, Manuel.

Referència: Commun Biol 2021.
Treatment of Hepatic Fibrosis in Mice Based on Targeted Plasmonic Hyperthermia

Autors:
Ribera, J; Vilches, C; Sanz, V; de Miguel, I; Portolés, I;

(...)

Prat, E; Nunes, V; Jiménez, W; Quidant, R; Morales-Ruiz, M.

Referència: ACS Nano 2021.
A SMALL POPULATION OF LIVER ENDOTHELIAL CELLS UNDERGOES ENDOTHELIAL TO MESENCHYMAL TRANSITION IN RESPONSE TO CHRONIC LIVER INJURY.

Autors:
Ribera, Jordi; Pauta, Montse; Melgar-Lesmes, Pedro; Cordoba, Bernat; Bosch, Anna;

(...)

Rodrigo-Torres, Daniel; Sancho-Bru, Pau; Mira, Aurea; Jimenez, Wladimiro; Morales-Ruiz, Manuel.

Referència: AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY 2017.
Akt-mediated foxo1 inhibition is required for liver regeneration

Autors:
Pauta, M; Rotllan, N; Fernandez-Hernando, A; Langhi, C; Ribera, J;

(...)

Ford, DA; Baldan, A; Birnbaum, MJ; Morales-Ruiz, M; Fernandez-Hernando, C.

Referència: HEPATOLOGY 2016.
Overexpression of angiopoietin-2 in rats and patients with liver fibrosis. Therapeutic consequences of its inhibition

Autors:
Pauta, Montse; Ribera, Jordi; Melgar-Lesmes, Pedro; Casals, Gregori; Rodriguez-Vita, Juan;

(...)

Bataller, Ramon; Michelena, Javier; Altamirano, Jose; Jimenez, Wladimiro; Morales-Ruiz, Manuel.

Referència: LIVER INTERNATIONAL 2015.
Endothelial Akt1 mediates angiogenesis by phosphorylating multiple angiogenic substrates

Autors:
Lee, Monica Y; Luciano, Amelia K; Ackah, Eric; Rodriguez-Vita, Juan; Bancroft, Tara A;

Eichmann, Anne; Simons, Michael; Kyriakides, Themis R; Morales-Ruiz, Manuel; Sessa, William C.

Referència: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2014.
Impaired liver regeneration in Ldlr-/- mice is associated with an altered hepatic profile of cytokines, growth factors, and lipids

Autors:
Pauta, Montse; Rotllan, Noemi; Vales, Frances; Fernandez-Hernando, Ana; Allen, Ryan M;

(...)

Mari, Montserrat; Jimenez, Wladimiro; Baldan, Angel; Morales-Ruiz, Manuel; Fernandez-Hernando, Carlos.

Referència: JOURNAL OF HEPATOLOGY 2013.

Projectes destacats

Function and therapeutic potential of RNA helicases and miR-122a-5p in liver regeneration and cancer

Investigador/a principal: Manuel Morales Ruiz

Finançador: Agencia Estatal de Investigacion (AEI)

Codi: PID2022-138243OB-I00

Durada: 01/10/2024 - 31/03/2026
Grup de recerca traslacional en noves estratègies de diagnòstic i tractament de la malaltia hepàtica

Investigador/a principal: Manuel Morales Ruiz

Finançador: Generalitat de Catalunya

Codi: 2021-SGR-00881

Durada: 01/01/2022 - 30/06/2025
Estimulacion de la regeneracion funcional de higados cirroticos mediante la normalizacion vascular intrahepatica y la modulacion de dianas de akt

Investigador/a principal: Manuel Morales Ruiz

Finançador: DGICYT (Dirección General de Investigación Científica y Técnica)

Codi: SAF2016-75358-R

Durada: 30/12/2016 - 31/12/2020
Nuevos mecanismos moleculares y nuevas estrategias terapéuticas aplicables a la conservación de la función hepática y a la mejora de la enfermedad hepática crónica

Investigador/a principal: Manuel Morales Ruiz

Finançador: Agencia Estatal de Investigacion (AEI)

Codi: PID2019-105502RB-I00

Durada: 01/01/2020 - 30/06/2023
Simvastatin and Rifaximin as new therapy for patients with decompensated cirrhosis (Liver Hope)

Investigador/a principal: Pere Ginès

Finançador: European Comission

Codi: CE_H2020- SC1_16abr1s-731875

Durada: 01/01/2017 - 28/02/2023

Manuel Morales-Ruiz

Grup de recerca

Publicacions destacades

Projectes destacats

Function and therapeutic potential of RNA helicases and miR-122a-5p in liver regeneration and cancer

Grup de recerca traslacional en noves estratègies de diagnòstic i tractament de la malaltia hepàtica

Estimulacion de la regeneracion funcional de higados cirroticos mediante la normalizacion vascular intrahepatica y la modulacion de dianas de akt

Nuevos mecanismos moleculares y nuevas estrategias terapéuticas aplicables a la conservación de la función hepática y a la mejora de la enfermedad hepática crónica

Simvastatin and Rifaximin as new therapy for patients with decompensated cirrhosis (Liver Hope)

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