Marianna Spatola

About me

Featured publications

• Clinical Characterization and Long-Term Outcome in Children and Adults With Anti-AMPA Receptor Encephalitis.

  Authors:

  Milano C; Saylam E; Papi C; Marmolejo L; Sankovic A;

  (...)

  Honnorat J; Graus F; Dalmau JO; Magaña S; Spatola M.

  See complete list of authors

  Reference: Neurology-Neuroimmunology & Neuroinflammation 2025.

• Assessing Commercial Tissue-Based Assays for Autoimmune Neurologic Disorders (I) Antibodies to Intracellular Antigens

  Authors:

  Milano, Chiara; Businaro, Pietro; Papi, Claudia; Arlettaz, Lionel; Marmolejo, Laura;

  (...)

  Ruiz-Garcia, Raquel; Sabater, Lidia; Dalmau, Josep O; Graus, Francesc; Spatola, Marianna.

  See complete list of authors

  Reference: Neurology-Neuroimmunology & Neuroinflammation 2025.

• Molecular scalpels dissect new GluN1 hot spots in anti-NMDA receptor encephalitis.

  Authors:

  Spatola M; Dalmau J;

  Reference: Science immunology 2025.

• Humoral signatures of Caspr2-antibody spectrum disorder track with clinical phenotypes and outcomes.

  Authors:

  Terroba-Navajas P; Spatola M; Chuquisana O; Joubert B; de Vries JM;

  (...)

  Prüss H; Wiendl H; Titulaer MJ; Honnorat J; Lünemann JD.

  See complete list of authors

  Reference: Med (N Y) 2024.

• Distinctive antibody responses to Mycobacterium tuberculosis in pulmonary and brain infection.

  Authors:

  Spatola M; Nziza N; Irvine EB; Cizmeci D; Jung W;

  (...)

  Thwaites G; Lauffenburger DA; Fortune S; Thuong NTT; Alter G.

  See complete list of authors

  Reference: BRAIN 2024.

• Humoral signatures of MOG-antibody-associated disease track with age and disease activity

  Authors:

  Spatola, M; Chuquisana, O; Jung, W; Lopez, JA; Wendel, EM;

  (...)

  Lauffenburger, DA; Rostásy, K; Brilot, F; Alter, G; Lünemann, JD.

  See complete list of authors

  Reference: Cell Rep Med 2023.

• Neurologic sequelae of COVID-19 are determined by immunologic imprinting from previous coronaviruses

  Authors:

  Spatola M; Nziza N; Jung W; Deng Y; Yuan D;

  (...)

  Chiodega V; Ferrari S; Lauffenburger DA; Mariotto S; Alter G.

  See complete list of authors

  Reference: BRAIN 2023.

• Human Metabotropic Glutamate Receptor 5 Antibodies Alter Receptor Levels and Behavior in Mice

  Authors:

  Maudes, Estibaliz; Mannara, Francesco; Garcia-Serra, Anna; Radosevic, Marija; Mellado, Araceli;

  Serafim, Ana Beatriz; Planaguma, Jesus; Sabater, Lidia; Dalmau, Josep; Spatola, Marianna.

  Reference: ANNALS OF NEUROLOGY 2022.

• Clinical features, prognostic factors, and antibody effects in anti-mGluR1 encephalitis

  Authors:

  Spatola, M; Pedrol, MP; Maudes, E; Simabukuro, M; Muñiz-Castrillo, S;

  (...)

  Smitt, PS; Honnorat, J; Rosenfeld, MR; Graus, F; Dalmau, J.

  See complete list of authors

  Reference: NEUROLOGY 2020.

Featured Projects

• Unravelling the role of neuronal antibodies and innate immunity partnership in human autoimmune encephalitis

  Principal investigator: Marianna Spatola

  Funder: European Research Council

  Duration: 01/06/2025 - 31/12/2030

• Microbiota and Innate Immune-Cell Engagement in Autoimmune Encephalitis (MICE-AE)

  Principal investigator: Marianna Spatola

  Funder: European Union

  Duration: 01/06/2025 - 31/05/2027

• Defining the role of antibody-innate immunity interplay in NMDAR encephalitis pathogenesis

  Principal investigator: Marianna Spatola

  Funder: Instituto de Salud Carlos III

  Duration: 01/01/2024 - 01/01/2026

• Functional role of antibodies against herpes simplex virus 1 in brain infection and autoimmunity

  Funder: La Caixa Foundation

  Duration: 01/01/2022 - 01/01/2025

• Identification of immune correlates of protection from herpes simplex virus 1 encephalitis

  Principal investigator: Marianna Spatola

  Funder: Swiss National Funding (FNS)

  Duration: 01/01/2020 - 01/01/2022