Search results

• Identification of athletes at risk of sudden death

  We aim to characterize cardiac remodelling in response to exercise training and to identify those atletes at risk of presenting sudden death. Also,...

  Research – Research lines

• Characterization of hypertrophic hearts (INDEPTH-HCM)

  We aim to perform a in-depth myocardial characterization of hypertrophic cardiomyopathy: comprehensive multimodality imaging, tissue characterizati...

  Research – Research lines

• Identification of candidates for and impact of percutaneous therapies for heart valve disease

  We aim to understand the changes in valvular geometry and cardiac performance before and after implantation of novel percutanoeusly implanted devic...

  Research – Research lines

• Usefulness of non-invasive cardíac imaging in the identification of acute coronary syndromes

  We explore the additive diagnostic value of several non-invasive cardiac imaging modalities for the identification of acute coronary syndrome among...

  Research – Research lines

• To investigate the role of mitochondrial DNA in synapse elimination and neurodegeneration in genetic models of neurodegenerative diseases

  The loss of neuronal synapses is a phenomenon that occurs in the early stages of neurodegenerative disorders. We hypothesize that synaptic neurodeg...

  Research – Research lines

• To study the mechanisms that alter amyloid beta (Aβ) clearance and disposal of dysfunctional mitochondria

  Ab accumulation is a primary step of Alzheimer’s disease (AD). Noteworthy, while in early-onset familial AD increased Ab burden mainly results from...

  Research – Research lines

• Study the role of mitochondrial function in neuroinflammation and amyloid beta (Aβ)-induced cell death

  Neuroinflammation is a key pathological feature of Alzheimer’s disease (AD) that results primarily from the presence of chronically activated micro...

  Research – Research lines

• Psychotic and affective disorders in children and adolescents

  Directed by Immaculada Baeza  The research line has been active for the last fourteen years. Both diseases are considered neurobiological disorder...

  Research – Research lines

• Anorexia and other eating disorders

  Directed by Immaculada Baeza  Our group has studied clinical, neuropsychological and brain alterations in adolescents diagnosed with these disorde...

  Research – Research lines

• Obsessive-compulsive disorder (OCD) and Tourette syndrome

  Directed by Luisa Lázaro  We study patients’ neuroimaging and genetic characteristics in order to differentiate endophenotypes and also use machin...

  Research – Research lines

• Autism spectrum disorders (ASD)

  Directed by Immaculada Baeza  Our group has published studies on cognitive and neuroimaging abnormalities in ASD children and adolescents and thei...

  Research – Research lines

• Involvement of p27 (Kip1) in cancer progression

  p27 (Kip1), a classical inhibitor of cyclin dependent kinases, is also a transcriptional regulator. We are analysing the mechanisms by which p27 re...

  Research – Research lines

• Protein kinases in cancer

  Our research focuses on identifying the molecular mechanism by which the CaMK family regulate cell cycle control and stress response. We are actual...

  Research – Research lines

• Myeloma and other monoclonal gammapathies

  Multiple myeloma and systemic AL amyloidosis. Minimal residual disease, extramedullary involvement in myeloma, cardiac involvement in amyloidosis,...

  Research – Research lines

• Mechanisms of progression in monoclonal gammopathies

  Mechanisms of  progression and control in patients with multiple myeloma. Molecular and cellular features of  patients with long-lasting stable mon...

  Research – Research lines

• Myeloid neoplasmas

  Natural history and prognosis of chronic myeloid leukemia, myeloproliferative neoplasms, acute myeloid leukemia and myelodysplastic syndromes; prog...

  Research – Research lines

• 1. Pathogenesis of osteoporosis and fracture development in primary biliary cholangitis and other chronic cholestatic disorders

  Based on our clinical and experimental studies on the development of osteoporosis in primary biliary cholangitis, we have confirmed its high preval...

  Research – Research lines

• 3. Osteoporosis in premenopausal women and in males. Clinical characteristics and mechanisms involved in the development of the disorder

  We have analyzed the factors associated with the development of osteoporosis in men and in premenopausal women. These studies are important because...

  Research – Research lines

• 2. Osteoporosis in liver transplantation

  For years we studied the characteristics of the bone pathology in patients before and after liver transplant. We recently evaluated whether the bon...

  Research – Research lines

• 4. Evaluation of bone remodelling regulators in the pathogenesis of osteoporosis

  We have analyzed the OPG/RANKL system in different conditions: chronic cholestasis and patients with spinal cord injury. We have also analyzed aspe...

  Research – Research lines