Search results

• Structural connectivity in multiple sclerosis

  Multicentric study within MAGNIMS group. This project is designed to provide high quality information on the changes in structural connectivity in...

  Research – Research lines

• Network mechanisms of working memory in the prefrontal cortex

  We combine computational model simulations with data analysis of electrophysiological single-neuron recordings from collaborating laboratories in o...

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• The role of NMDARs in working memory

  We are investigating the specific deficits in working memory of patients recovering from anti-NMDAR encephalitis. We study their behavioral paramet...

  Research – Research lines

• The role of NMDARs in slow-wave sleep

  We investigate sleep patterns in anti-NMDAR encephalitis patients by recording polysomnogram and EEG longitudinally as patients recover from the di...

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• The NMDAR hypothesis of schizophrenia

  NMDAR hypofunction has been hypothesized as a possible mechanism of schizophrenia. By comparing behavioral, EEG and fMRI parameters between anti-NM...

  Research – Research lines

• The multifaceted mitochondria: obesity, diabetes and beyond

  Directed by Marc Claret  We have several projects aimed at understanding neuron-type specific mitochondrial biology, from many different angles (d...

  Research – Research lines

• Cell-type specific epigenetics and obesity

  Directed by Marc Claret  We use cutting-edge genetic models to unravel the epigenetic landscape of specific subpopulations of neurons under obesog...

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• Endothelial cells: new players in metabolic disorders

  Directed by Marc Claret  We are also interested in understanding the influence of endothelial cells in systemic metabolic control and in the devel...

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• Neuronal Heterogeneity and Functional Specialization

  Directed by Marc Claret  Our research focuses on understanding how neuronal heterogeneity within key hypothalamic circuits contributes to the prec...

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• Endophenotypes, genetics and biomarkers of affective disorders

  Our group is involved in national and international projects that are contributing to important advances in the field of the genetic and epigenetic...

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• Epidemiology and disability associated with bipolar and unipolar disorders

  Affective disorders are among the leading causes of disability worldwide, and the development of treatments aimed to prevent or diminish functional...

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• First affective and psychotic episodes

  Our group is focused on early intervention as a critical paradigm for improving disease outcomes, via the evaluation of patients with first episode...

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• Innovative psychological interventions for bipolar disorder and depression

  Our group has developed novel psychological interventions for the treatment of affective disorders, i.e. psychoeducation, family intervention, func...

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• Neurocognition and neuroimaging of bipolar and unipolar disorders

  The group has been a pioneer in the characterization of the neurocognitive alterations associated with affective disorders, both in hot and cold co...

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• Observational studies in affective disorders

  Our group has led sevral observational studies in bipolar disorder and in depressed patients (such as the BRIDGE study) with recent focus on treatm...

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• Psychometrics of mental disorders

  In addition, the research team has developed new clinical scales for the screening of affective disorders and the assessment of cognitive impairmen...

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• Pathophysiology, diagnosis and treatment of portal hypertension

  Directed by Juan Carlos García‑Pagán His research research is centered on the pathophysiology, diagnosis and treatment of portal hypertension and...

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• Mechanisms of liver inflammation and fibrosis

  Chronic liver injury is characterized by an important inflammatory response and an increase in extracellular matrix deposition, which may lead to l...

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• Liver cell plasticity

  The liver has remarkable cell plasticity. Lineage tracing studies have shown the potential of biliary-to-hepatocyte as well as hepatocyte-to-biliar...

  Research – Research lines

• In vitro disease modeling

  In vitro liver models have emerged as excellent tools to better understand liver pathology, to test new therapeutic drugs and for toxicity testing...

  Research – Research lines