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• Frailty & Sarcopenia in Liver Diseases Hepatic Encephalopathy

  Directed by Anna Baiges Aznar Her research focus on developing new therapies for hepatic encephalopathy and how functional status and physiologic...

  Research – Research lines

• Molecular mechanisms of endolysosomal homeostasis and extracellular vesicles.

  Directed by Albert Lu The endolysosomal compartment is central to metabolic and signaling control. It is also the site where exosomes form and are...

  Research – Research lines

• Investigation of pathophysiological mechanisms in neurodegenerative dementias

  Directed by Raquel Sánchez-Valle and Anna Antonell The research aims of Sánchez-Valle and Antonell are to identify and validate key proteins invol...

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• Role of the locus coeruleus and sleep disturbances in neurodegenerative dementias

  Directed by Neus Falgàs  Falgàs investigates how early degeneration of the locus coeruleus and associated noradrenergic dysfunction contribute to...

  Research – Research lines

• Clinical laboratory innovation and precision diagnostics

  Directed by Manuel Morales-Ruiz We drive the research and clinical translation of advanced diagnostic tools in biochemistry, toxicology and molecu...

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• Glia-neuron crosstalk in Huntington’s disease

  Directed by Silvia Ginés To understand the differences underlying the mechanisms regulating mitochondrial dynamics within astrocytes and neurons...

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• Neural plasticity in neurological and neuropsychiatric disorders

  Directed by Albert Giralt Characterization of new genetic risk factors in Alzheimer's disease and the study of new therapeutic strategies. Char...

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• Monitoring and modulating neural circuits in brain disorders

  Directed by Mercè Masana To determine circuit dysfunction and early network vulnerability in Huntington's disease using fMRI and fiber photometr...

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• Neural stem cells and brain damage

  Directed by Daniel Tornero Neuronal replacement in stem cell therapies for stroke-damaged brain. Functional studies in neuronal networks using...

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• Generative AI for neuroscience in silico modeling

  Directed by Jordi Abante The Abante lab advances neuroscience by creating advanced in silico models that leverage cutting-edge machine learning to...

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• Functional genomics of neurodegenerative diseases

  Directed by Eulalia Martí We investigate how non-coding RNAs regulate gene expression networks driving age-related neurodegenerative diseases, aim...

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• Nursing care of patients with chronic liver diseases

  Directed by Nuria Fabrellas The research team led by Prof. Núria Fabrellas is internationally recognized for advancing nursing care in chronic liv...

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• Development of open automated systems for finely-controlled animal behavioral experiments

  Directed by Hernando Martinez Vergara and Jaime de la Rocha With the support of the European Research Council Proof-of-Concept and a project Prueb...

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• Cell of origin and somatic mosaicism in normal lymphocytes

  We aim to investigate the normal cellular counterparts of lymphoid neoplasms and the earliest genetic alterations that precede malignant transforma...

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• Immunogenomics of lymphoid neoplasms

  We investigate the immunogenetic, genomic and transcriptomic features that shape the biology and clinical behavior of lymphoid neoplasms. Our work...

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• Evolutionary trajectories driving lymphoid neoplasms progression and transformation

  Our research aims to reconstruct the life histories of lymphoid tumors from their earliest detectable stages to advanced disease. By combining evol...

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• Genetic and non-genetic mechanisms of resistance

  We aim to understand why some patients fail to respond or eventually relapse after treatment. Our research focuses on both genetic and non-genetic...

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• Assay and algorithm development. Innovation and knowledge transfer

  We develop molecular assays and computational tools that facilitate the translation of immunogenomic discoveries into clinical practice. This inclu...

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• Establishment of Lenvatinib + Pembrolizumab + TACE as an alternative therapeutic approach for intermediate HC

  We led a randomized controlled trial comparing lenvatinib plus pembrolizumab plus TACE versus dual placebo plus TACE, which demonstrated superiorit...

  Research – Research lines

• Establishment of the trial design and endpoint guidelines for EASL-AASLD-ASCO-ILCA

  This is a muti-society consensus on trial design and endpoints that gathered 102 recommendations on this area of expertise. A panel of 16 members p...

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