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Schizophrenia is a disorder associated with a shortened telomere, a marker of increased mortality rate and aging and impaired cellular immunity. However, treatment may confound these relationships. We examined the relationship of glucose tolerance, white blood cell count and telomere length with schizophrenia in newly diagnosed antipsychotic-naïve patients.
Cognitive remediation therapy positively affects cognition and daily functioning in patients with schizophrenia. However, studies on the underlying neurobiological mechanisms of this treatment are scarce. The aim of our project is to investigate functional and structural connectivity brain changes in schizophrenia patients after cognitive remediation therapy using a whole-brain approach that combined functional magnetic resonance imaging and diffusion tensor imaging.
Molecular neurobiology of schizophrenia
Research about Endocannabinoid System (ECS) dysregulation in peripheral blood mononuclear cells of First Episodes Psychosis patients. The alteration of the ECS presented at the initial phases of psychosis could be contributing to the pathophysiology of the disease and constitutes a possible biomarker of psychotic disorders and an interesting pharmacological target to take into account.
First episodes and second schizophrenia episodes
Multicenter, naturalistic, prospective, longitudinal research designed to evaluate clinical, neuropsychological, neuroimaging, biochemical, environmental and pharmacogenetic variables in a sample of first episode of psychosis patients and healthy controls. The PEPs project is conducted in Spain since January 2009.
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El IDIBAPS-FCRB busca profesionales con talento para cubrir las necesidades que surgen de forma periódica.