Publicaciones destacadas

Introducing Allopurinol to the Medical Treatment of Marfan Syndrome: Advantages, Limitations, and Potential Extension to other Aortopathies

Egea, Gustavo; de Souza, Rodrigo Barbosa; Teixido-Tura, Gisela; Mas-Stachurska, Aleksandra; Evangelista, Arturo;

Loeys, Bart.

Referencia:
CARDIOVASCULAR DRUGS AND THERAPY 2026.
Dysfunctional Mitochondria in the Cardiac Fibers of a Williams-Beuren Syndrome Mouse Model

Abdalla, N; Tobías-Baraja, E; Gonzalez, A; Garrabou, G; Egea, G;

Campuzano, V.

Referencia:
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023.
The Combined Treatment of Curcumin with Verapamil Ameliorates the Cardiovascular Pathology in a Williams–Beuren Syndrome Mouse Model

Noura Abdalla; Paula Ortiz‐Romero; Isaac Rodríguez-Rovira; Luís A. Pérez-Jurado; Gustavo Egea;

Victoria Campuzano.

Referencia:
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023.
Allopurinol blocks aortic aneurysm in a mouse model of Marfan syndrome via reducing aortic oxidative stress

Rodríguez-Rovira I; Arce C; De Rycke K; Pérez B; Carretero A;

(...)

Teixidò-Turà G; Gómez-Cabrera MC; Campuzano V; Jiménez-Altayó F; Egea G.

Referencia:
FREE RADICAL BIOLOGY AND MEDICINE 2022.
Anti-TGFβ (Transforming Growth Factor β) Therapy with Betaglycan-Derived P144 Peptide Gene Delivery Prevents the Formation of Aortic Aneurysm in a Mouse Model of Marfan Syndrome

Arce, C; Rodríguez-Rovira, I; De Rycke, K; Durán, K; Campuzano, V;

Fabregat, I; Jiménez-Altayó, F; Berraondo, P; Egea, G.

Referencia:
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2021.
Co-Treatment With Verapamil and Curcumin Attenuates the Behavioral Alterations Observed in Williams–Beuren Syndrome Mice by Regulation of MAPK Pathway and Microglia Overexpression

Ortiz-Romero, P; González-Simón, A; Egea, G; Pérez-Jurado, LA; Campuzano, V;

Referencia:
Frontiers in Pharmacology 2021.
A FBN1 3′UTR mutation variant is associated with endoplasmic reticulum stress in aortic aneurysm in Marfan syndrome

Siegert, Anna-Maria; Garcia Diaz-Barriga, Gerardo; Esteve-Codina, Anna; Navas-Madronal, Miguel; Gorbenko del Blanco, Darya;

Alberch, Jordi; Heath, Simon; Galan, Maria; Egea, Gustavo.

Referencia:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2019.
REDOX STRESS IN MARFAN SYNDROME: DISSECTING THE ROLE OF THE NADPH OXIDASE NOX4 IN AORTIC ANEURYSM.

Jimenez-Altayo, Francesc; Meirelles, Thayna; Crosas-Molist, Eva; Alba Sorolla, M; Gorbenko del Blanco, Darya;

(...)

Laurindo, Francisco; Schroeder, Katrin; Ros, Joaquim; Fabregat, Isabel; Egea, Gustavo.

Referencia:
FREE RADICAL BIOLOGY AND MEDICINE 2018.
Altered TGF-β endocytic trafficking contributes to the increased signaling in Marfan syndrome

Siegert A; Serra-Peinado C; Gutiérrez-Martínez E; Rodríguez-Pascual F; Fabregat I;

Egea G.

Referencia:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2018.
MicroCT imaging reveals differential 3D micro-scale remodelling of the murine aorta in ageing and marfan syndrome

López-Guimet J.; Peña-Pérez L.; Bradley R.; García-Canadilla P.; Disney C.;

(...)

Bodey A.; Withers P.; Bijnens B.; Sherratt M.; Egea G..

Referencia:
Theranostics 2018.