José Ignacio Martín-Subero

Sobre mí

Publicaciones destacadas

• Insight into genetic predisposition to chronic lymphocytic leukemia from integrative epigenomics

  Autores: Speedy HE, Beekman R, Chapaprieta V, Orlando G, Law PJ, Martín-García D, Gutiérrez-Abril J, Catovsky D, Beà S, Clot G, Puiggròs M, Torrents D, Puente XS, Allan JM, López-Otín C, Campo E, Houlston RS, Martín-Subero JI .

  Referencia: Nature Communications 2019.

• Insight into origins, mechanisms & utility of DNA methylation in B cell malignancies.

  Autores: Oakes CC; Martin-Subero JI.

  Referencia: Blood 2018.

• Charting the dynamic epigenome during B-cell development

  Autores: Martin-Subero J; Oakes C.

  Referencia: Seminars In Cancer Biology 2018.

• The reference epigenome and regulatory chromatin landscape of chronic lymphocytic leukemia

  Autores: Beekman R, Chapaprieta V, Russiñol N, Vilarrasa-Blasi R, Verdaguer-Dot N, Martens JHA, Duran-Ferrer M, Kulis M, Serra F, Javierre BM, Wingett SW, Clot G, Queirós AC, Castellano G, Blanc J, Gut M, Merkel A, Heath S, Vlasova A, Ullrich S, Palumbo E, Enjuanes A, Martín-García D, Beà S, Pinyol M, Aymerich M, Royo R, Puiggros M, Torrents D, Datta A, Lowy E, Kostadima M, Roller M, Clarke L, Flicek P, Agirre X, Prosper F, Baumann T, Delgado J, López-Guillermo A, Fraser P, Yaspo ML, Guigó R, Siebert R, Martí-Renom MA, Puente XS, López-Otín C, Gut I, Stunnenberg HG, Campo E, Martin-Subero JI .

  Referencia: Nature Medicine 2018.

• Decoding the DNA Methylome of Mantle Cell Lymphoma in the Light of the Entire B Cell Lineage

  Autores: Queiros, Ana C.; Beekman, Renee; Vilarrasa-Blasi, Roser; Duran-Ferrer, Marti; Clot, Guillem; Merkel, Angelika; Raineri, Emanuele; Russinol, Nuria; Castellano, Giancarlo; Bea, Silvia; Navarro, Alba; Kulis, Marta; Verdaguer-Dot, Nuria; Jares, Pedro; Enjuanes, Anna; Jose Calasanz, Maria; Bergmann, Anke; Vater, Inga; Salaverria, Itziar; van de Werken, Harmen J. G.; Wilson, Wyndham H.; Datta, Avik; Flicek, Paul; Royo, Romina; Martens, Joost; Gine, Eva; Lopez-Guillermo, Armando; Stunnenberg, Hendrik G.; Klapper, Wolfram; Pott, Christiane; Heath, Simon; Gut, Ivo G.; Siebert, Reiner; Campo, Elias; Martin-Subero, Jose I.;.

  Referencia: Cancer Cell 2016.

• Whole-genome fingerprint of the DNA methylome during human B cell differentiation

  Autores: Kulis, Marta; Merkel, Angelika; Heath, Simon; Queiros, Ana C.; Schuyler, Ronald P.; Castellano, Giancarlo; Beekman, Renee; Raineri, Emanuele; Esteve, Anna; Clot, Guillem; Verdaguer-Dot, Nuria; Duran-Ferrer, Marti; Russinol, Nuria; Vilarrasa-Blasi, Roser; Ecker, Simone; Pancaldi, Vera; Rico, Daniel; Agueda, Lidia; Blanc, Julie; Richardson, David; Clarke, Laura; Datta, Avik; Pascual, Marien; Agirre, Xabier; Prosper, Felipe; Alignani, Diego; Paiva, Bruno; Caron, Gersende; Fest, Thierry; Muench, Marcus O.; Fomin, Marina E.; Lee, Seung-Tae; Wiemels, Joseph L.; Valencia, Alfonso; Gut, Marta; Flicek, Paul; Stunnenberg, Hendrik G.; Siebert, Reiner; Kueppers, Ralf; Gut, Ivo G.; Campo, Elias; Martin-Subero, Jose I.;.

  Referencia: Nature Genetics 2015.

• Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers

  Autores: Agirre, Xabier; Castellano, Giancarlo; Pascual, Marien; Heath, Simon; Kulis, Marta; Segura, Victor; Bergmann, Anke; Esteve, Anna; Merkel, Angelika; Raineri, Emanuele; Agueda, Lidia; Blanc, Julie; Richardson, David; Clarke, Laura; Datta, Avik; Russinol, Nuria; Queiros, Ana C.; Beekman, Renee; Rodriguez-Madoz, Juan R.; San Jose-Eneriz, Edurne; Fang, Fang; Gutierrez, Norma C.; Garcia-Verdugo, Jose M.; Robson, Michael I.; Schirmer, Eric C.; Guruceaga, Elisabeth; Martens, Joost H. A.; Gut, Marta; Calasanz, Maria J.; Flicek, Paul; Siebert, Reiner; Campo, Elias; San Miguel, Jesus F.; Melnick, Ari; Stunnenberg, Hendrik G.; Gut, Ivo G.; Prosper, Felipe; Martin-Subero, Jose I.;.

  Referencia: Genome Research 2015.

• A B-cell epigenetic signature defines three biologic subgroups of chronic lymphocytic leukemia with clinical impact

  Autores: Queirós A., Villamor N., Clot G., Martinez-Trillos A., Kulis M., Navarro A., Penas E., Jayne S., Majid A., Richter J., Bergmann A., Kolarova J., Royo C., Russiñol N., Castellano G., Pinyol M., Bea S., Salaverria I., López-Guerra M., Colomer D., Aymerich M., Rozman M., Delgado J., Giné E., González-Díaz M., Puente X., Siebert R., Dyer M., López-Otín C., Rozman C., Campo E., López-Guillermo A., Martín-Subero J..

  Referencia: Leukemia 2015.

• Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia

  Autores: Kulis, Marta; Heath, Simon; Bibikova, Marina; Queiros, Ana C; Navarro, Alba; Clot, Guillem; Castellano, Giancarlo; Brun-Heath, Isabelle; Pinyol, Magda; Barberan-Soler, Sergio; Papasaikas, Panagiotis; Jares, Pedro; Bea, Silvia; Rico, Daniel; Ecker, Simone; Rubio, Miriam; Royo, Romina; Ho, Vincent; Klotzle, Brandy; Hernandez, Lluis; Conde, Laura; Lopez-Guerra, Monica; Colomer, Dolors; Villamor, Neus; Aymerich, Marta; Rozman, Maria; Bayes, Monica; Gut, Marta; Gelpi, Josep L; Orozco, Modesto; Fan, Jian-Bing; Quesada, Victor; Puente, Xose S; Pisano, David G; Valencia, Alfonso; Lopez-Guillermo, Armando; Gut, Ivo; Lopez-Otin, Carlos; Campo, Elias; Martin-Subero, Jose I.

  Referencia: Nature Genetics 2012.

Proyectos destacados

• Deciphering the pathogenetic and clinical role of aberrant DNA methylation of enhancer elements in chronic lymphocytic leukemia

  Investigador/a principal: José Ignacio Martín Subero

  Financiador: Universitat de Barcelona (Sede o evento); World Cancer Research Fund International ; Universitat de Barcelona (Participante)

  Código: 16-1285

  Duración: 01/07/2016 - 30/06/2019

• Functional and clinical impact of enhancer DNA methylation in mantle cell lymphoma

  Investigador/a principal: José Ignacio Martín Subero

  Financiador: Institut D'investigacions Biomediques August Pi i Sunyer (Idibaps) (Sede o evento); Institut D'investigacions Biomediques August Pi i Sunyer (Idibaps) (Participante); European Hematology Association (EHA)

  Duración: 16/11/2014 - 15/11/2017

• Análisi del (hidroxi)metiloma sencer de I'ADN i del transcriptoma en el Mieloma Múltiple

  Investigador/a principal: José Ignacio Martín Subero

  Código: 20132130

  Duración: 01/01/2014 - 01/01/2017

• A BLUEPRINT of Haematopoietic Epigenomes

  Investigador/a principal: José Ignacio Martín Subero

  Financiador: Institut D'investigacions Biomediques August Pi i Sunyer (Idibaps) (Sede o evento); Institut D'investigacions Biomediques August Pi i Sunyer (Idibaps) (Participante); European Commission (EC)

  Código: FP7-Health-1ST-11 (282510)

  Duración: 01/10/2011 - 30/09/2017

• Caracterización epigenómica de las neoplasias hematológicas

  Investigador/a principal: José Ignacio Martín Subero

  Código: SAF2009-08663

  Duración: 10/11/2010 - 31/12/2012