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The goal of this line emerges from the recent results derived from the integrative analysis of the proteome and transcriptome from human sperm, ooc...
Exosomes contained in the seminal fluid may contribute proteins and RNAs to the sperm. Our first goal is to characterize the protein and RNA conten...
We have identified a non-random distribution of proteins and genes along the sperm chromatin domains which may represent epigenetic marks involved...
Molecular alterations at the transcriptiomic and proteomic level are analyzed in sperm and seminal plasma from couples with idiopathic infertility...
We are studying the genetic aspects of hereditary endocrine disorders (multiple endocrine neoplasia, congenital adrenal hyperplasia and monogenic...
Differentiated familial thyroid carcinoma represents 3-9% of thyroid carcinomas. Today, the genes involved in some rare syndromic forms in which th...
Oncogenesis is essentially a cell dedifferentiation process. Molecules that induce cell differentiation, such as retinoic acid, have been used for...
Examples: 1) Identification of the pattern of cannabis, tobacco, and alcohol use as a function of gender and psychiatric comorbidities that predic...
Studies at our lab have identified the value of uric acid administration after a brain embolism and how it acts in synergy with reperfusion therapi...
Mechanical thrombectomy (MT) increases brain reperfusion and the likelihood of good outcome in patients with acute stroke but only about one third...
Blood-brain barrier (BBB) disruption is one of the major deleterious mechanisms implicated in the physiopathology of Central Nervous System disease...
Infection is a frequent complication of stroke associated with mortality and poor neurological recovery. Recent experimental studies show that post...
Vascular dementia (VaD) is recognized as one of the leading causes of cognitive impairment and dementia in the elderly, and has become one of the m...
Brain cell death after acute stroke triggers inflammation, involving glial and endothelial cell activation, invasion of leukocytes to the damaged t...
The sphingolipid rehostat greases the machinery of cell death unleashing the molecular players involved in the execution of cell death in its diver...
As cholesterol is a major determinant of the structural properties of membrane bilayers, we aimed to understand the mechanisms underlying the intra...
As the biology of mice and humans differ, we have developed and established a model of mice with humanized liver, which may increase the translatio...
Disect the role of the mutual regulation between sphingolipids and cholesterol in lysosomes and mitochondrial turnover in the regulation of drug in...
We aimed to study the impact of mitochondrial cholesterol and glycosphingolipids in the stabilization/activation of HIF1a and its impact in the pr...
Our purpose is to understand the impact of mitochondrial cholesterol in adipose tissue and muscle and their interplay in insulin resistance and non...