Resultados de búsqueda

• Evidence-based syntheses in mental health

  Directed by Joaquim Raduà We conduct syntheses (e.g., meta-analyses, mega-analyses and umbrella reviews) of variables and processes involved in me...

  Investigación – Líneas de investigación

• Integrative genetic profile and identification diagnostic markers

  In order to achieve the complete global genetic landscape of these rare tumors we are studying the molecular profile of poorly characterized Non-Ho...

  Investigación – Líneas de investigación

• Study of intratumoral heterogeneity

  Data already obtained in the analysis of pediatric NHL shows the presence of intratumoral heterogeneity that may represent the existence of differe...

  Investigación – Líneas de investigación

• Identification of genetic biomarkers and drug targets

  Our final goal is to identify target genes/pathways that can be useful biomarkers in the management of pediatric NHL. In detail, we aim to identify...

  Investigación – Líneas de investigación

• 1-Cancer Stem Cells and Cell Plasticity in Cancer

  Cell plasticity predisposes cells to malignant transformation. Tumor cells lose their previously normal identity and function and, through a cellul...

  Investigación – Líneas de investigación

• 2-Stem Cells, Cell Differentiation and Tissue Regeneration

  Normal cells and tissues are continuously adapting themselves to exogenous challenges. Stem cell plasticity is central to the adaptation and regene...

  Investigación – Líneas de investigación

• 3-Cell Plasticity in Immune Cells during Inflammation in Tissue Regeneration and Cancer

  Inflammation has positive and negative functions. On the one hand, inflammation is a normal response of the body to infections and injury. The migr...

  Investigación – Líneas de investigación

• 1. Ischemia-reperfusion injury and expanding criteria for liver graft acceptance

  Maintaining the viability of organs from their recovery to transplantation is a key factor for transplant success and graft survival. Organ damage...

  Investigación – Líneas de investigación

• 2. Endoscopic management of biliary complications following liver transplantation

  The study of biliary complications after liver transplantation has high clinical relevance, due it relatively high incidence, complexity of managem...

  Investigación – Líneas de investigación

• 3. Expanding indications for liver transplantation in relation to pre-existing portal vein thrombosis and portal hypertension

  It is widely known that portal vein thrombosis is a serious complication of chronic liver disease, and the prognosis of liver transplantation depen...

  Investigación – Líneas de investigación

• 4. Expanding indications for transplantation for malignant tumors – hilar cholangiocarcinoma and colorectal cancer liver metastases

  The decrease in the number of patients on liver transplant waiting lists due to the advent of effective treatment for hepatitis C virus has generat...

  Investigación – Líneas de investigación

• 5. Alloimmune response, complications associated with immunosupression, and operational tolerance

  Treatment with immunosupression is associated with a series of risks for the transplanted patient, making minimization key to optimizing post-trans...

  Investigación – Líneas de investigación

• 6. Prevention and treatment of cardiovascular risk factors following liver transplantation

  Cardiovascular diseases represent one of the most common causes of long-term morbidity and mortality after liver transplantation. This group focuse...

  Investigación – Líneas de investigación

• Clinical applicability of genomic copy-number alterations and aneuploidy

  Chromosomal aneuploidy results in the acquisition of copy-number alterations, which occur early in tumorigenesis and are positively selected throug...

  Investigación – Líneas de investigación

• Intratumor heterogeneity as a novel biomarker in colorectal cancer

  Elucidating the role of genomic instability, which represents the molecular engine that fuels intratumor heterogeneity in carcinomas, is critical f...

  Investigación – Líneas de investigación

• Functional consequences of whole-genome doubling and its impact on disease outcome

  There is growing evidence that whole-genome doubling occurs early in tumorigenesis and triggers genetically unstable near-tetraploid cells. In addi...

  Investigación – Líneas de investigación

• 1-Which is the role of translational control of gene expression in liver disease and cancer?

  To understand the molecular mechanisms involved in the development and progression of liver disease and cancer, with a focus on the aberrant reprog...

  Investigación – Líneas de investigación

• 2-What is the significance and underlying mechanisms linking obesity with liver disease and cancer?

  To decipher mechanisms underpinning the detrimental impact of obesity in liver disease and cancer. This knowledge is crucial for advancements in tr...

  Investigación – Líneas de investigación

• 3-How does deregulation of pathways that control angiogenesis contribute to progression of liver disease and cancer?

  To define the molecular and cellular mechanisms that regulate/dysregulate angiogenesis in liver disease and cancer and define their functional rele...

  Investigación – Líneas de investigación

• 2-Multiple sclerosis and other demyelinating syndromes

  This work is leading to a comprehensive understanding of the etiology and pathophysiology of demyelinating disorders including multiple sclerosis,...

  Investigación – Líneas de investigación