Resultados de búsqueda

• New technologies and biomarkers in dialysis

  Directed by Dr. Francesc Maduell During the last years we analyzed and improved the quality of dialysis, especially studying vascular calcificatio...

  Investigación – Líneas de investigación

• Pathophisiology and innovative therapies in acute and chronic kidney disease

  Directed by Dr. Luis F Quintana and Dr Miquel Blasco. We were studying endothelial dysfunction and complement disorders in the context of chronic...

  Investigación – Líneas de investigación

• Artificial intelligence

  Directed by Dr. Ignacio Revuelta We are developing predictive AI models that classify patients in terms of their immunological risk and, consequen...

  Investigación – Líneas de investigación

• Novel biomarkers and clinical relevance of the persistence of cccDNA in chronic HBV infection

  There is no curative treatment for HBV infection. This is mainly due to the persistence of cccDNA (covalently closed circular DNA) in the nucleus o...

  Investigación – Líneas de investigación

• Natural history of chronic HBV infection in different clinical situations

  There are very few data on the role of the immune response (and especially of the specific or adaptive) in the viral events that characterize the n...

  Investigación – Líneas de investigación

• Clinical, virological and immunological predictors of response after antiviral treatment interruption in chronic hepatitis B

  Despite the existence of an efficient hepatitis B vaccine for more than 30 years, hepatitis B virus (HBV) infection is still a global health proble...

  Investigación – Líneas de investigación

• Characterization of humoral and intrahepatic HBV immune responses and the effect of antiviral therapy

  Although most studies have focused on the analysis of T cell responses in chronic hepatitis B, humoral / B cell responses are important for prevent...

  Investigación – Líneas de investigación

• Strategies of hepatitis C microelimination in our geographical area, focused in PWID and psychiatric populations

  Significant scale-up of treatment among people who inject drugs (PWID) is crucial to achieve WHO hepatitis C virus (HCV) elimination targets. We ha...

  Investigación – Líneas de investigación

• Long-term impact of Hepatitis C cure in patients with advanced liver disease

  Portal hypertension (PH) is the key driver of hepatic decompensation in patients with advanced chronic liver disease. Accordingly, interventions th...

  Investigación – Líneas de investigación

• Understanding the immunopathogenesis of autoimmune hepatitis (AIH) to develop risk stratification tools at presentation

  The incidence of AIH has been steadily increasing within the last decades.  However, standard treatment of the disease, which consists of corticost...

  Investigación – Líneas de investigación

• Evolution of AIH in special populations (pregnancy, compensated and decompensated cirrhosis)

  Approximately 30% of patients with AIH have cirrhosis at the time of diagnosis, and 20-30% of the remaining patients will develop cirrhosis during...

  Investigación – Líneas de investigación

• Identification of biomarkers of success of immunosuppression withdrawal and treatment response in AIH

  We have performed a prospective clinical trial to identify biomarkers able to predict the success of immunosuppression withdrawal in patients with...

  Investigación – Líneas de investigación

• Natural history of modern primary biliary cholangitis (PBC) and predictive factors of portal hypertension in patients in non-cirrhotic patients with PBC

  PBC is chronic liver disease affecting small bile ducts. If left untreated, patients will develop ductopenia and cirrhosis with all its complicatio...

  Investigación – Líneas de investigación

• Impact of exercise programs in the treatment PBC-associated fatigue

  Up to 50% of patients with PBC experience clinically significant fatigue and, it is more common in younger patients. Fatigue diminishes quality of...

  Investigación – Líneas de investigación

• Clinical and biological characterization of patients with Wilson’s disease

  Wilson's Disease is a rare genetic condition characterized by copper deposition mainly in the liver and other tissues afterwards. Clinical presenta...

  Investigación – Líneas de investigación

• Epidemiology of drug-induced liver disease

  The real incidence of drug-induced liver injury is difficult, but it seems clear that it is increasing due to the growth of prescriptions. Epidemio...

  Investigación – Líneas de investigación

• CAR-T cells for the treatment of solid tumours

  After the success of CAR-T cells in hematologic malignancies, the translation of CAR-T cells to solid tumours is the next big challenge in the fiel...

  Investigación – Líneas de investigación

• CAR-T cells for the treatment of hematologic malignancies

  Resistance to CD19-CAR-T cells in hematologic malignancies can appear linked to loss or downregulation of CD19 expression or an immunosuppressive t...

  Investigación – Líneas de investigación

• Understanding the limitations of CAR-T cells in preclinical studies

  The progress of CAR-T cells is limited by a poor understanding of how the design and signaling of these CAR proteins affect T cell efficacy and per...

  Investigación – Líneas de investigación

• Other cancer immunotherapies and combination treatments

  While T-cell based immunotherapies have revolutionized cancer treatment, a majority of patients fail to respond or relapse after a certain period o...

  Investigación – Líneas de investigación