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The main lines of global research are as follows, with the ultimate goal of finding a treatment to prevent and/or cure the disease:
In vitro studies. The properties of the normal protein and the pathological prion protein are evaluated and pharmacological modifications are studied in the laboratory.
The drugs currently under research are involved in pre-clinical studies. Animal models are used to evaluate the effectiveness of new medicines prior to them being used in humans. These models assess the mechanisms that induce a protein to develop into a ‘diseased’ prion form, and how it causes damage to the brain tissue.
Existing clinical studies are conducted in patients and at-risk subjects to improve diagnostic and prognostic tools. There are currently no drug studies in which new patients diagnosed with prion diseases can participate.
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Substantiated information by:
Jordi Sarto Alonso
Raquel Sanchez del Valle DíazNeurology Head of Department
Published: 21 December 2021
Updated: 21 December 2021
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