Cell biology, intracellular compartments and cancer
We focus on the molecular mechanisms that drive tumor progression and treatment resistance, identifying therapeutic targets capable of preventing cancer dissemination
Current research
Problem
Cancer is one of the most prevalent diseases in developed countries. Although great progress has been made in early detection and treatment, no effective strategies exist as yet in the majority of cases. The cells that are resistant to treatment continue to proliferate, forming new tumours, even in tissues far from the initial tumour site, thus generating metastasis, the main cause of death in patients.
Approach
Our group aims to improve cancer therapies by preventing tumor cell growth, migration, and treatment resistance. We study how normal cellular mechanisms become altered in cancer, which allows us to identify vulnerabilities that can guide new treatment approaches. By focusing on the molecular changes involved in tumor progression and treatment resistance, we can identify therapeutic targets and develop new functional tools to advance precision medicine against cancer, in collaboration with oncologists.
Impact
Our group studies the control of cell death, DNA replication, and the function of oncogenic proteins such as RAS, which are frequently mutated in human tumors. We have identified new strategies to block tumor cell growth, migration, and treatment resistance, thereby promoting the restoration of cell death. We have also developed new tools and therapies for personalized cancer treatment, in collaboration with international oncologists, demonstrating how basic research can positively influence cancer treatment and clinical outcomes.