Appointment of Josep M. Miró, Group leader
Infections of the heart and cardiovascular system are very serious and require the actions of a multidisciplinary team of experts to improve their prevention, diagnosis and treatment

Current research

Problem

Endocarditis is a disease that has severe effects on a patient’s quality of life. It has high morbidity and mortality rates, as it affects the heart as well as other organs such as the brain. Surgical treatment is necessary in more than fifty per cent of cases.

Making progress in the study of these infections requires an interdisciplinary approach, from basic in vitro and in vivo laboratory research in an experimental endocarditis model to clinical-translational research. This is the only way to prevent it and to optimise its diagnosis and its medical and surgical treatments.

Approach

Our principal objective is to transfer basic scientific knowledge to daily clinical practice. This is achieved by optimising the monitoring of these types of infections; improving clinical imaging and laboratory diagnostic techniques; developing new, effective treatment strategies adapted to current epidemiological changes; and studying improved surgical approaches and strategies to prevent complications.

The group is made up of experts in infections, microbiology, cardiology, cardiac and electrophysiological imaging, heart surgery, nuclear medicine, neurology and anatomical pathology.

Impact

The results of our studies can have an important impact on society, as they can lead to: earlier diagnosis of these diseases; the identification of new antibiotics, antibiotic combinations and therapeutic strategies that are effective for treating cardiovascular infections; better determination of the best time for heart surgery in diseases involving cardiovascular infections; and the prevention of post-operative cardiovascular infections and those that develop in patients with heart disease.

The conclusions of the studies that we have conducted may be incorporated into national and international clinical guidelines.