Alterations in the interactions between organelles within neurons cause obesity

Marc Claret, researcher at the IDIBAPS Laboratory of Diabetes and Obesity, Ramon Gomis, director of IDIBAPS, and Enric Banda, director of the Department of Science, Research and Environment of the Obra Social " la Caixa", presented this morning at CosmoCaixa a study on the causes of obesity published today in by Cell and highlighted on its cover. It is well known that the hormone leptin plays a central role on the regulation of hunger in the brain. This molecule is secreted by adipose tissue to suppress appetite when enough food has been eaten. Many obese people are resistant to the effects of leptin despite having large amounts of it in their blood, but the molecular cause why this resistance appears is still unknown.