The talk summarized the recent works of the speaker, and was centered in three microRNAs. When inhibited, miR-375 affects beta cell proliferation and compensation. When overexpressed, miR-200 induces beta cell apoptosis and miR-7 stimulate beta cell differentiation and insulin secretion. These molecules have a significant influence in the apparition of diabetes and its progression.
The researches presented by Dr. Markus Stoffel included experimental models as well as human samples. In the last years he has published several works in the Nature magazine, underlining the importance of microRNAs. His last work in Nature defines a critical role for deregulated expression of miR-802 in the development of obesity-associated impairment of glucose metabolism.
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