Identified a mechanism responsible for the pathological response of the heart to sustained overload

Researchers from USA, Spain and Italy discovered a molecular mechanism responsible for the pathological response of the heart to intense and sustained overload. This mechanism is mediated by the APJ receptor, very similar to the angiotensin-receptor, and associated until now with a cardioprotective activity. The relevance of this finding lays in the fact that it was thought that the APJ function could only be beneficial for the heart. Some drugs are being designed aimed at increasing its activity.