Clínic Barcelona

IDIBAPS investigators describe the genetic profile of an uncommon subtype of mantle cell lymphoma improving its proper diagnosis

Mantle cell lymphoma (MCL)is a subtype of B-cell lymphoma that comprises about 6-7% of all non-Hodgkin's lymphoma cases. The main biomarker of this usually aggressive lymphoma is an alteration in Cyclin D1 expression. An article led by IDIBAPS investigators, and published in Blood(1), characterizes a new subtype of MCLs in which Cyclin D1 expression is not altered and offers clues to close different controversies about the genetics of the disease. Dr. Itziar Salaverria is the first author of the article, while the Miguel Servet investigator Dr. Sílvia Beà is the last one, both from the Human and experimental functional oncomorphology IDIBAPS team led by Dr. Elías Campo. Due to its significance, the article was highlighted by its editors as one of the "hottest" manuscripts to the media and selected for a comment (2) in the last issue of the Blood magazine.