Clínic Barcelona

IDIBAPS researchers identify a new therapeutic target for liver cancer

IDIBAPS researchers have identified the first epi-driver in liver cancer, a type of epigenetic alteration in the IGF2 gene that causes tumors to grow. In the study, published in the Gastroenterology journal, they have found that this alteration occurs in 15% of tumors and that a monoclonal antibody can effectively block it and slow tumor progression in animal models. Dr. Josep M. Llovet, ICREA Professor, Head of the Translational research in hepatic oncology IDIBAPS group and Director of the Mount Sinai Liver Cancer Program at Icahn School of Medicine at Mount Sinai (New York), has coordinated this study. The first authors of the article are Iris Martínez-Quetglas and Roser Pinyol, researchers at the same team.