Prof. Reiner Siebert started his presentation with a historical introduction to lymphomas highlighting the major contributions made by Kiel researchers over more than one century. He then summarized some recent results obtained by his laboratory and in the context of international collaborative studies such as the International Cancer Genome Consortium (ICGC) on Malignant Lymphoma coordinated by him. He and his collaborators pursue a global approach to B-cell lymphomas, trying to integrate all the clinical, genomic, epigenomic and personal data available. In particular, he presented next-generation sequencing data on Burkitt lymphomas and the identification of ID3 as the most frequently mutated gene in this disease.
The research led by the speaker also studies the relation between genetic alterations, epigenetic changes and development of a malignant lymphoma in the context of the age of the patient. Finally, Prof. Siebert spoke about sequential samples of patients with lymphoma and identified different patterns of clonal evolution based on genetic and epigenetic data.