Sofía Pérez-Del-Pulgar

Research group

Viral, genetic and immune-mediated liver diseases Accredited researcher (R3A)

sofiapp@clinic.cat 0000-0002-9890-300X

Featured publications

Aberrant integration of Hepatitis B virus DNA promotes major restructuring of human hepatocellular carcinoma genome architecture

Authors:
Alvarez, Eva G; Demeulemeester, Jonas; Otero, Paula; Jolly, Clemency; Garcia-Souto, Daniel;

(...)

Garaigorta, Urtzi; Campbell, Peter J; Nakagawa, Hidewaki; Van Loo, Peter; Tubio, Jose M C.

Reference: Nature Communications 2021.
Modeling hepatitis C virus kinetics during liver transplantation reveals the role of the liver in virus clearance

Authors:
Shekhtman, Louis; Navasa, Miquel; Sansone, Natasha; Crespo, Gonzalo; Subramanya, Gitanjali;

(...)

Perelson, Alan S; Cotler, Scott J; Forns, Xavier; Uprichard, Susan L; Dahari, Harel.

Reference: Elife 2021.
Viral and immune factors associated with successful treatment withdrawal in HBeAg-negative chronic hepatitis B patients

Authors:
Garcia-Lopez, Mireia; Lens, Sabela; Pallett, Laura J; Testoni, Barbara; Rodriguez-Tajes, Sergio;

(...)

Koutsoudakis, George; Zoulim, Fabien; Maini, Mala K; Forns, Xavier; Perez-del-Pulgar, Sofia.

Reference: Journal Of Hepatology 2021.
Hepatitis C virus intrinsic molecular determinants may contribute to the development of cholestatic hepatitis after liver transplantation

Authors:
Gambato, Martina; Gregori, Josep; Quer, Josep; Koutsoudakis, George; Gonzalez, Patricia;

(...)

Ignacio Esteban, Juan; Crespo, Gonzalo; Navasa, Miquel; Forns, Xavier; Perez-del-Pulgar, Sofia.

Reference: Journal Of General Virology 2019.
Hepatitis C virus early kinetics and resistance-associated substitution dynamics during antiviral therapy with direct-acting antivirals.

Authors:
Perpinan, Elena; Caro-Perez, Noelia; Garcia-Gonzalez, Neris; Gregori, Josep; Gonzalez, Patricia;

(...)

Koutsoudakis, George; Quer, Josep; Gonzalez-Candelas, Fernando; Forns, Xavier; Perez-del-Pulgar, Sofia.

Reference: Journal Of Viral Hepatitis 2018.
Phylogenetic analysis of an epidemic outbreak of acute hepatitis C in HIV-infected patients by ultra-deep pyrosequencing

Authors:
Caro-Perez, Noelia; Martinez-Rebollar, Maria; Gregori, Josep; Quer, Josep; Gonzalez, Patricia;

(...)

Ignacio Esteban, Juan; Mallolas, Josep; Forns, Xavier; Laguno, Montse; Perez-del-Pulgar, Sofia.

Reference: Journal Of Clinical Virology 2017.
Tuning a cellular lipid kinase activity adapts hepatitis C virus to replication in cell culture

Authors:
Harak, Christian; Meyrath, Max; Romero-Brey, Ines; Schenk, Christian; Gondeau, Claire;

(...)

Vondran, Florian W. R.; De Francesco, Raffaele; Rice, Charles M.; Bartenschlager, Ralf; Lohmann, Volker;.

Reference: Nature Microbiology 2017.
Hepatitis C Virus RNA Persists in Liver Explants of Most Patients Awaiting Liver Transplantation Treated With an Interferon-Free Regimen

Authors:
Gambato, Martina; Perez-del-Pulgar, Sofia; Hedskog, Charlotte; Svarovskia, Evguenia S; Brainard, Diana;

(...)

Charlton, Michael; Caro-Perez, Noelia; Carlota Londono, Maria; Koutsoudakis, George; Forns, Xavier.

Reference: Gastroenterology 2016.
Clinical relevance of the study of hepatitis B virus covalently closed circular DNA

Authors:
Kumar R.; Pérez-del-Pulgar S.; Testoni B.; Lebossé F.; Zoulim F.;

Reference: Liver International 2016.
Hepatitis C virus infection inhibits P-body granule formation in human livers

Authors:
Perez-Vilaro, Gemma; Fernandez-Carrillo, Carlos; Mensa, Laura; Miquel, Rosa; Sanjuan, Xavier;

Forns, Xavier; Perez-del-Pulgar, Sofia; Diez, Juana.

Reference: Journal Of Hepatology 2015.

Featured Projects

Study of cccDNA persistence during HBV infection in vivo, and in vitro using a bioreactor that mimics the liver microenvironment

Principal investigator: Sofia Perez del Pulgar Gallart

Funder: Instituto de Salud Carlos III

Code: PI16/00111

Duration: 01/01/2017 - 31/12/2019
Virological and immunological factors associated with hepatitis C and hepatitis B virus infection recurrence after treatment discontinuation

Principal investigator: Xavier Forns Bernhardt

Funder: Gilead España

Duration: 07/03/2016 - 06/03/2018
TherVacB: A therapeutic vaccine to cure hepatitis B

Principal investigator: Xavier Forns Bernhardt

Funder: European Commission

Code: 848223

Duration: 01/01/2020 - 31/12/2024

Web: https://www.thervacb.eu/
Interplay between HBV, HDV and host factors: impact on liver disease progression (InBDeL)

Principal investigator: Sofia Perez del Pulgar Gallart

Funder: ISCIII

Code: PI19/00036

Duration: 01/01/2020 - 31/12/2022
Viral and immune factors associated with antiviral treatment and hepatitis C recurrence after liver transplantation

Principal investigator: Sofia Perez del Pulgar Gallart

Funder: Instituto de Salud Carlos III

Code: PI13/00155

Duration: 01/01/2014 - 30/03/2017

Sofía Pérez-Del-Pulgar

Research group

Featured publications

Featured Projects

Study of cccDNA persistence during HBV infection in vivo, and in vitro using a bioreactor that mimics the liver microenvironment

Virological and immunological factors associated with hepatitis C and hepatitis B virus infection recurrence after treatment discontinuation

TherVacB: A therapeutic vaccine to cure hepatitis B

Interplay between HBV, HDV and host factors: impact on liver disease progression (InBDeL)

Viral and immune factors associated with antiviral treatment and hepatitis C recurrence after liver transplantation

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