Search results

• Lineage-specification of pMHC-NP-induced antigen-specific T-regulatory type 1 (TR1) cells

  This project seeks to define the mechanisms underlying the lineage origin and specification of the autoreactive TR1 cells arising in response to pM...

  Research – Research lines

• Phenotypic, transcriptional and epigenetic make up of pMHC-NP-induced human autoantigen-specific TR1 cells in humanized mouse models

  We seek to define the phenotypic, transcriptional and epigenetic make-up of human autoantigen-specific TR1 cells arising in humanized mice in respo...

  Research – Research lines

• Advancing antigen-specific nanomedicines for the treatment of organ-specific and systemic autoimmune diseases

  This project involves the development of novel methodologies to identify candidate pMHC-based nanomedicines for a variety of chronic inflammatory d...

  Research – Research lines

• Role of autophagy in autoantigen presentation during T-cell ontogeny and autoimmunity

  This line of research focuses on studying the role of autophagy in the presentation of type 1 diabetes-relevant autoantigens by thymic and peripher...

  Research – Research lines

• Engineering of recombinant peptide-major histocompatibility complexes suitable for eliciting autoreactive T-regulatory type 1 cells in vivo

  This projects seeks to engineer novel recombinant pMHC structures suitable for human therapeutic application.

  Research – Research lines

• Understanding pancreatic carcinogenesis

  Directed by Dr. Cristina Fillat  Pancreatic carcinogenesis is well defined as a multistage process accompanied by distinct morphological and histo...

  Research – Research lines

• Oncolytic virotherapies against pancreatic cancer

  Directed by Dr. Cristina Fillat  Oncolytic adenoviruses replicate in the tumors leading to oncolysis and triggering an immune cell infiltration in...

  Research – Research lines

• Preclinical gene therapy /genome editing studies for metabolic rare diseases

  Directed by Dr. Cristina Fillat  Glutaric aciduria type I (GA-I) is a metabolic inherited disease due to mutations in the GCDH gene. Individuals w...

  Research – Research lines

• Utility of cardiac magnetic resonance in the diagnosis and treatment of arrhythmias

  Obtaining MRI and analysis of the arrhythmia substrate using specialized software. 

  Research – Research lines

• Role of sinusoidal cells in the progression and regression of liver diseases

  We aim at comprehensively characterizing the molecular mechanisms responsible for sinusoidal cells de-regulation during the progression of liver pa...

  Research – Research lines

• Sinusoidal communications in liver diseases

  Using original bioengineered in vitro models, we aim at describing the effects that modifications in sinusoidal biomechanics, occurring during live...

  Research – Research lines

• Aging & liver diseases

  Considering the increase in worldwide population median age and life expectancy, we devote a significant part of our resources at characterizing, i...

  Research – Research lines

• Molecular pathology of B-cell neoplasms

  Directed by Elías Campo To characterize the molecular alterations involved in the development and progression of lymphoid neoplasms, particularly...

  Research – Research lines

• Oncogene mediated genome instability and transcriptional stress in the progression of lymphoid neoplasms

  Directed by Pedro Jares Our research focuses on understanding the molecular mechanisms behind the genomic instability and transcriptional dysregul...

  Research – Research lines

• Non-coding RNA alterations in the pathogenesis on B-cell lymphoid neoplasms

  Directed by Lluis Hernández We focus on finding non-coding RNAs (mainly microRNAs and long non-coding RNAs) as biomarkers of interest in the clini...

  Research – Research lines

• MRI and genetic markers of multiple sclerosis long-term progression

  Observational study to explore the biology of progression in multiple sclerosis using genetic approaches coupled with neuroimage-based tissue pheno...

  Research – Research lines

• Cognitive rehabilitation and brain plasticity in multiple sclerosis

  A randomized controlled clinical study: Study to evaluate the efficacy of cognitive rehabilitation in patients with multiple sclerosis that presen...

  Research – Research lines

• Structural connectivity in multiple sclerosis

  Multicentric study within MAGNIMS group. This project is designed to provide high quality information on the changes in structural connectivity in...

  Research – Research lines

• Network mechanisms of working memory in the prefrontal cortex

  We combine computational model simulations with data analysis of electrophysiological single-neuron recordings from collaborating laboratories in o...

  Research – Research lines

• The role of NMDARs in working memory

  We are investigating the specific deficits in working memory of patients recovering from anti-NMDAR encephalitis. We study their behavioral paramet...

  Research – Research lines