Search results

• Mitochondrial cholesterol and glycosphingolipids in liver fibrosis. Reciprocal regulation between HIF1a and StARD1 in steatohepatitis and hepatocellular carcinoma

  We aimed to study the impact of mitochondrial cholesterol and glycosphingolipids in the stabilization/activation of HIF1a and its impact  in the pr...

  Research – Research lines

• ER stress-mitochondrial cholesterol axis in obesity-associated insulin resistance and comorbidities

  Our purpose is to understand the impact of mitochondrial cholesterol in adipose tissue and muscle and their interplay in insulin resistance and non...

  Research – Research lines

• Lysosomal proteases role during tissue remodeling and regeneration in liver and kidney injury

  This research line focuses on identifying new therapeutic targets for liver and kidney disease treatment by studying the cellular and molecular pat...

  Research – Research lines

• Development of physiomimetic experimental models

  The use of physiomimetic experimental models is transforming respiratory research by providing biomimetic environments that closely replicate lung...

  Research – Research lines

• Optimization of stem cell therapy for acute lung injury

  Development of a stem cell training program based on individual effects of different biomechanical environmental paràmetres to produce highly thera...

  Research – Research lines

• Mechanisms of cardiac arrhythmias in high-level athletes

  Heavily trained athletes have been found to be at a higher risk of atrial fibrillation and right ventricular arrhythmias than their sedentary count...

  Research – Research lines

• Extra-cardiac consequences of very high-intensity physical activity

  The deleterious consequences of high-intensity physical activity may not be limited to the heart. We are currently interested in testing whether he...

  Research – Research lines

• Characterization of the pathophysiology of cardiac arrhythmias

  We are also interested in uncovering the mechanisms of the deleterious atrial arrhythmogenic cardiac remodelling occurring in the absence of overt...

  Research – Research lines

• Understanding the biogenesis and consumption of lipid droplets: decoding the metabolic syndrome?

  Directed by Albert Pol  Accumulation of lipid droplets is the cellular hallmark of a plethora of prevalent diseases. Understanding the life-cycle...

  Research – Research lines

• Lipid droplets as innate immunity hubs

  Directed by Albert Pol  We recently described a new antimicrobial function of cytosolic lipid droplets in the cellular defence against intracellul...

  Research – Research lines

• Lipid droplets role in inflammation

  Directed by Marta Bosch  Lipid droplets are accumulated in multiple inflammatory processes. With especial attention to the pro-inflammatory transc...

  Research – Research lines

• Lipid droplets, a new cancer hallmark

  Directed by Albert Pol  Lipid droplets are a hallmark of multiple cancers, our research focuses in understanding their role in liquid tumours to d...

  Research – Research lines

• Lineage-specification of pMHC-NP-induced antigen-specific T-regulatory type 1 (TR1) cells

  This project seeks to define the mechanisms underlying the lineage origin and specification of the autoreactive TR1 cells arising in response to pM...

  Research – Research lines

• Phenotypic, transcriptional and epigenetic make up of pMHC-NP-induced human autoantigen-specific TR1 cells in humanized mouse models

  We seek to define the phenotypic, transcriptional and epigenetic make-up of human autoantigen-specific TR1 cells arising in humanized mice in respo...

  Research – Research lines

• Advancing antigen-specific nanomedicines for the treatment of organ-specific and systemic autoimmune diseases

  This project involves the development of novel methodologies to identify candidate pMHC-based nanomedicines for a variety of chronic inflammatory d...

  Research – Research lines

• Role of autophagy in autoantigen presentation during T-cell ontogeny and autoimmunity

  This line of research focuses on studying the role of autophagy in the presentation of type 1 diabetes-relevant autoantigens by thymic and peripher...

  Research – Research lines

• Engineering of recombinant peptide-major histocompatibility complexes suitable for eliciting autoreactive T-regulatory type 1 cells in vivo

  This projects seeks to engineer novel recombinant pMHC structures suitable for human therapeutic application.

  Research – Research lines

• Understanding pancreatic carcinogenesis

  Directed by Dr. Cristina Fillat  Pancreatic carcinogenesis is well defined as a multistage process accompanied by distinct morphological and histo...

  Research – Research lines

• Oncolytic virotherapies against pancreatic cancer

  Directed by Dr. Cristina Fillat  Oncolytic adenoviruses replicate in the tumors leading to oncolysis and triggering an immune cell infiltration in...

  Research – Research lines

• Preclinical gene therapy /genome editing studies for metabolic rare diseases

  Directed by Dr. Cristina Fillat  Glutaric aciduria type I (GA-I) is a metabolic inherited disease due to mutations in the GCDH gene. Individuals w...

  Research – Research lines